Recombinant Mouse Cd74 protein (rFc Tag)

Species

Mouse

Purity

>90 %, SDS-PAGE

Tag

rFc Tag

Activity

not tested

Cat no : Eg2716



Product Information

Purity >90 %, SDS-PAGE
Endotoxin <1.0 EU/μg protein, LAL method
Activity
Not tested
Expression HEK293-derived Mouse Cd74 protein Gln56-Leu279 (Accession# P04441-1) with a rabbit IgG Fc tag at the C-terminus.
GeneID 16149
Accession P04441-1
PredictedSize 28.0 kDa
SDS-PAGE
Formulation Lyophilized from sterile PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization.
Reconstitution Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water.
Storage Conditions
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
  • Until expiry date, -20℃ to -80℃ as lyophilized proteins.
  • 3 months, -20℃ to -80℃ under sterile conditions after reconstitution.
Shipping The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature.

Background

CD74, also known as the invariant chain or HLA class II histocompatibility antigen gamma chain, is a type II transmembrane protein primarily expressed on antigen-presenting cells (APCs). It functions intracellularly as a chaperone for MHC class II molecules, facilitating their assembly and transport to the cell surface. CD74 also serves as a cell surface receptor for macrophage migration inhibitory factor (MIF), playing a role in cell survival and proliferation. Additionally, CD74 has been implicated in various diseases, including cancers and immune-related conditions, making it a potential therapeutic target.

References:

1. Bucala, Richard, and Idit Shachar. Mini reviews in medicinal chemistry vol. 14,14 (2014): 1132-8. 2. Li, Qiu-Lin et al. Frontiers in cardiovascular medicine vol. 9 (2023): 1049143. 3. Vargas, Jasmine, and Georgios Pantouris. International journal of molecular sciences vol. 24,21 (2023): 15981. 4. David, Keren et al. Cell reports vol. 41,5 (2022): 111572.