Recombinant Mouse Cd74 protein (rFc Tag)
Species
Mouse
Purity
>90 %, SDS-PAGE
Tag
rFc Tag
Activity
not tested
Cat no : Eg2716
Validation Data Gallery
Product Information
| Purity | >90 %, SDS-PAGE |
| Endotoxin | <1.0 EU/μg protein, LAL method |
| Activity |
Not tested |
| Expression | HEK293-derived Mouse Cd74 protein Gln56-Leu279 (Accession# P04441-1) with a rabbit IgG Fc tag at the C-terminus. |
| GeneID | 16149 |
| Accession | P04441-1 |
| PredictedSize | 28.0 kDa |
| SDS-PAGE | |
| Formulation | Lyophilized from sterile PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization. |
| Reconstitution | Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water. |
| Storage Conditions |
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
|
| Shipping | The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature. |
Background
CD74, also known as the invariant chain or HLA class II histocompatibility antigen gamma chain, is a type II transmembrane protein primarily expressed on antigen-presenting cells (APCs). It functions intracellularly as a chaperone for MHC class II molecules, facilitating their assembly and transport to the cell surface. CD74 also serves as a cell surface receptor for macrophage migration inhibitory factor (MIF), playing a role in cell survival and proliferation. Additionally, CD74 has been implicated in various diseases, including cancers and immune-related conditions, making it a potential therapeutic target.
References:
1. Bucala, Richard, and Idit Shachar. Mini reviews in medicinal chemistry vol. 14,14 (2014): 1132-8. 2. Li, Qiu-Lin et al. Frontiers in cardiovascular medicine vol. 9 (2023): 1049143. 3. Vargas, Jasmine, and Georgios Pantouris. International journal of molecular sciences vol. 24,21 (2023): 15981. 4. David, Keren et al. Cell reports vol. 41,5 (2022): 111572.