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Recombinant Mouse ESM1 protein (rFc Tag)(HPLC verified)

Species

Mouse

Purity

>90 %, SDS-PAGE
>90 %, SEC-HPLC

Tag

rFc Tag

Activity

not tested

Cat no : Eg2784

Validation Data Gallery

  • Purity of Recombinant Mouse ESM1 was determined by SDS-PAGE. The protein was resolved in an SDS-PAGE in reducing (R) and non-reducing (NR) conditions and stained using Coomassie blue.

    Purity of Recombinant Mouse ESM1 was determined by SDS-PAGE. The protein was resolved in an SDS-PAGE in reducing (R) and non-reducing (NR) conditions and stained using Coomassie blue.

  • The purity of Mouse ESM1 was greater than 90% as determined by SEC-HPLC.

    The purity of Mouse ESM1 was greater than 90% as determined by SEC-HPLC.

Product Information

Purity >90 %, SDS-PAGE
>90 %, SEC-HPLC
Endotoxin <0.1 EU/μg protein, LAL method
Activity 
Not tested
Expression HEK293-derived Mouse ESM1 protein Ala22-Arg184 (Accession# Q9QYY7) with a rabbit IgG Fc tag at the C-terminus.
GeneID 71690
Accession Q9QYY7
PredictedSize 43.8 kDa
SDS-PAGE 40-48 kDa, reducing (R) conditions
Formulation Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization.
Reconstitution Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water.
Storage Conditions
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
  • Until expiry date, -20℃ to -80℃ as lyophilized proteins.
  • 3 months, -20℃ to -80℃ under sterile conditions after reconstitution.
Shipping The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature.

Background

Endothelial cell specific molecule 1 (ESM1), also known as endocan, is a secreted protein that is involved in endothelium-dependent pathological disorders. ESM1 is overexpressed in various tumors such as lung cancer, head and neck squamous cell carcinoma as well as ovarian cancer and overexpression of ESM1 is reported to induce tumor formation through regulating cell proliferation and facilitating tumor growth. ESM1 function is mainly associated with inflammatory response, angiogenesis and tumor cell growth.

References:

1.Liu W, et al. (2024) Ann Transl Med. 20;12(5):104.
2.Li J, et al. (2022) Biomed Res Int. 2022:5328192.
3.Li YK, et al. (2023) Int J Biol Sci. 19(1):258-280.
4.Yang L, et al. (2023) Aging (Albany NY). 15(8):2920-2936.
5.Yang J, et al. (2023) Cancers (Basel). 16(1):194.
6.Zhang J, et al. (2024) Mol Cancer. 23(1):94.