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Recombinant Mouse JAM-A/Junctional Adhesion Molecule A protein (rFc Tag) (HPLC verified)

Species

Mouse

Purity

>90 %, SDS-PAGE
>90 %, SEC-HPLC

Tag

rFc Tag

Activity

not tested

Cat no : Eg3117

Validation Data Gallery

  • Purity of Recombinant Mouse JAM-A was determined by SDS-PAGE. The protein was resolved in an SDS-PAGE in reducing (R) and non-reducing (NR) conditions and stained using Coomassie blue.

    Purity of Recombinant Mouse JAM-A was determined by SDS-PAGE. The protein was resolved in an SDS-PAGE in reducing (R) and non-reducing (NR) conditions and stained using Coomassie blue.

  • The purity of Mouse JAM-A was greater than 90% as determined by SEC-HPLC.

    The purity of Mouse JAM-A was greater than 90% as determined by SEC-HPLC.

Product Information

Purity >90 %, SDS-PAGE
>90 %, SEC-HPLC
Endotoxin <0.1 EU/μg protein, LAL method
Activity 
Not tested
Expression HEK293-derived Mouse JAM-A protein Lys27-Gly238 (Accession# O88792) with a rabbit IgG Fc tag at the C-terminus.
GeneID 16456
Accession O88792
PredictedSize 48.9 kDa
SDS-PAGE 50-52 kDa, reducing (R) conditions
Formulation Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization.
Reconstitution Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water.
Storage Conditions
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
  • Until expiry date, -20℃ to -80℃ as lyophilized proteins.
  • 3 months, -20℃ to -80℃ under sterile conditions after reconstitution.
Shipping The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature.

Background

F11 receptor (F11R), also called Junctional Adhesion Molecule-A (JAM-A), is a transmembrane protein that belongs to the immunoglobulin superfamily of cell adhesion molecules. F11R is present in epithelial cells, endothelial cells, leukocytes, and blood platelets. F11R participates in regulating various biological processes, as diverse as paracellular permeability, tight junction formation and maintenance, leukocyte transendothelial migration, epithelial-to-mesenchymal transition, angiogenesis, reovirus binding, and platelet activation.

References:

1.Fang TJ. et al. (2016) Int J Rheum Dis. 19(2):127-133.
2.Czubak-Prowizor K. et al. (2022) Mol Cell Biochem. 477(1):79-98. 
3.Kamola P. et al. (2023) Platelets. 34(1):2214618.