Recombinant Mouse IL-13 protein (His Tag)

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• Recombinant Mouse IL-13 protein (His Tag) (Eg0266)

Species

Mouse

Purity

>90 %, SDS-PAGE

Tag

His Tag

Activity

not tested

Publications

1

Cat no : Eg0266

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Validation Data Gallery

• 

  Purity of Recombinant Mouse IL-13 was determined by SDS-PAGE. The protein was resolved in an SDS-PAGE in reducing (R) conditions and stained using Coomassie blue.

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Product Information

• Purity: >90 %, SDS-PAGE
• Endotoxin: <0.1 EU/μg protein, LAL method
• Activity:

  Not tested

• Expression: HEK293-derived Mouse IL-13 protein Ser26-Phe131 (Accession# P20109) with a His tag at the C-terminus.
• GeneID: 16163
• Accession: P20109
• PredictedSize: 15.5 kDa
• SDS-PAGE: 18-32 kDa, reducing (R) conditions
• Formulation: Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization.
• Reconstitution: Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water.
• Storage Conditions:
  It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
  • Until expiry date, -20℃ to -80℃ as lyophilized proteins.
  • 3 months, -20℃ to -80℃ under sterile conditions after reconstitution.
• Shipping: The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature.

Background

Interleukin 13 (IL-13) is an immunoregulatory cytokine produced primarily by activated Th2 cells. This cytokine is involved in several stages of B-cell maturation and differentiation. IL-13 up-regulates CD23 and MHC class II expression, and promotes IgE isotype switching of B cells. IL-13 inhibits the production of a series of cytokines like IL-1, IL-6, TNF-alpha, and IL-8 by activated human monocytes. IL-13 induces IFN-gamma production by NK cells. IL-13 is thought to be important cytokine in the pathogenesis of asthma, and more recently has been shown to play a pivotal role in a number of fibrotic diseases including hepatic and pulmonary fibrosis, and nodular sclerosing Hodgkin's disease.

References:

1. Adamo ML. et al. (1993) Adv Exp Med Biol. 343:1-11.
2. Adachi Y. et al. (2019) J Gastroenterol Hepatol. 2019 Jun 3.
3. Anisimov VN. et al. (2019) Crit Rev Oncol Hematol. 87(3):201-23.
4. Sonntag WE. et al. (2012) J Gerontol A Biol Sci Med Sci. 67(6):587-98.

Publications

Species	Title
mouse	Nat Commun; Time-staggered chemo-immunotherapy via engineered nanofiber resists postoperative dynamic immunosuppression in glioblastoma.; Authors - Mingjie Song