Recombinant Mouse IL-20 protein (rFc Tag)

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• Recombinant Mouse IL-20 protein (rFc Tag) (Eg2797)

Species

Mouse

Purity

>90 %, SDS-PAGE

Tag

rFc Tag

Activity

not tested

Cat no : Eg2797

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Validation Data Gallery

• 

  Purity of Recombinant Mouse IL-20 was determined by SDS-PAGE. The protein was resolved in an SDS-PAGE in reducing (R) and non-reducing (NR) conditions and stained using Coomassie blue.

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Product Information

• Purity: >90 %, SDS-PAGE
• Endotoxin: <0.1 EU/μg protein, LAL method
• Activity:

  Not tested

• Expression: HEK293-derived Mouse IL-20 protein Leu25-Leu176 (Accession# Q9JKV9) with a rabbit IgG Fc tag at the C-terminus.
• GeneID: 58181
• Accession: Q9JKV9
• PredictedSize: 43.6 kDa
• SDS-PAGE: 39-48 kDa, reducing (R) conditions
• Formulation: Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization.
• Reconstitution: Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water.
• Storage Conditions:
  It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
  • Until expiry date, -20℃ to -80℃ as lyophilized proteins.
  • 3 months, -20℃ to -80℃ under sterile conditions after reconstitution.
• Shipping: The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature.

Background

As a member of the IL-10 family, IL-20 functions as a proinflammatory cytokine by binding to its complex receptors (IL-20R1/IL-20R2 and IL-20R2/IL-22R1) on target cells. Excessive IL-20 expression is associated with chronic inflammatory diseases, such as rheumatoid arthritis and osteoporosis.

References:

1. Wang HH. et al. (2022). J Biomed Sci. 29(1):36.
2. Hsu YH. et al. (2011). J Exp Med. 208(9):1849–1861.
3. Hsu YH. et al. (2017). Drug Discov Today. 22(6):960–964.