Recombinant Mouse IL-20RB protein (rFc Tag)

Species

Mouse

Purity

>90 %, SDS-PAGE

Tag

rFc Tag

Activity

not tested

Cat no : Eg3168

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Validation Data Gallery

• 

  Purity of Recombinant Mouse IL-20RB was determined by SDS-PAGE. The protein was resolved in an SDS-PAGE in reducing (R) conditions and stained using Coomassie blue.

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Product Information

• Purity: >90 %, SDS-PAGE
• Endotoxin: <0.1 EU/μg protein, LAL method
• Activity:

  Not tested

• Expression: HEK293-derived Mouse IL-20RB protein Val27-Ser225 (Accession# E9Q9A6) with a rabbit IgG Fc tag at the C-terminus.
• GeneID: 213208
• Accession: E9Q9A6
• PredictedSize: 48.3 kDa
• SDS-PAGE: 50-65 kDa, reducing (R) conditions
• Formulation: Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization.
• Reconstitution: Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water.
• Storage Conditions:
  It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
  • Until expiry date, -20℃ to -80℃ as lyophilized proteins.
  • 3 months, -20℃ to -80℃ under sterile conditions after reconstitution.
• Shipping: The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature.

Background

Interleukin-20 receptor subunit beta (IL-20RB) is a component of the interleukin-20 receptor (IL-20R) complex. This receptor complex plays a significant role in immune regulation, tissue homeostasis, host defense, and oncogenesis. The interaction with these cytokines leads to the activation of the JAK/STAT signaling pathway, influencing various immune responses. IL-20RB has been implicated in various diseases, particularly in the context of autoimmune diseases and cancer.

References:

1.Chen J, et al. (2018). J Leukoc Biol. 104(5):953-959.
2.He Y, et al. (2022). J Clin Invest. 132(20):e157917. 
3.Li XH, et al. (2023). J Transl Med. 21(1):911.