Recombinant Mouse LTBR/TNFRSF3 protein (C-rFc)

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• Recombinant Mouse LTBR/TNFRSF3 protein (C-rFc) (Eg6278)

Species

Mouse

Purity

>90 %, SDS-PAGE

Tag

rFc Tag

Activity

not tested

Cat no : Eg6278

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Validation Data Gallery

• 

  Purity of Recombinant Mouse LTBR was determined by SDS-PAGE. The protein was resolved in an SDS-PAGE in reducing (R) and non-reducing (NR) conditions and stained using Coomassie blue.

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Product Information

• Purity: >90 %, SDS-PAGE
• Endotoxin: <0.1 EU/μg protein, LAL method
• Activity:

  Not tested

• Expression: HEK293-derived Mouse LTBR protein Gln31-Leu223 (Accession# P50284) with a rabbit IgG Fc tag at the C-terminus.
• GeneID: 17000
• Accession: P50284
• PredictedSize: 47.3 kDa
• SDS-PAGE: 53-65 kDa , reducing (R) conditions
• Formulation: Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization.
• Reconstitution: Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water.
• Storage Conditions:
  It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
  • Until expiry date, -20℃ to -80℃ as lyophilized proteins.
  • 3 months, -20℃ to -80℃ under sterile conditions after reconstitution.
• Shipping: The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature.

Background

Lymphotoxin-beta receptor (LTBR) is also named TNFRSF3 and Tumor necrosis factor receptor type III (TNF-RIII; TNFR-III). LTBR is a receptor for the heterotrimeric lymphotoxin containing LTA and LTB, and for TNFS14/LIGHT. It can activate the NF-kappa-B signaling pathway upon stimulation with lymphotoxin (LTA1-LTB2). LTBR is constitutively expressed on stromal cells and myeloid lineage cells but not on T or B lymphocytes, which may be a novel immune checkpoint of tumor-associated macrophages.

References:

1.Sudhamsu, Jawahar et al. Proceedings of the National Academy of Sciences of the United States of America vol. 110,49 (2013): 19896-901.
2.Wolf, M J et al. Oncogene vol. 29,36 (2010): 5006-18.
3.Wang, Liang et al. iMeta vol. 3,5 e233. 4 Sep. 2024