Recombinant Mouse NKG2C/CD159c protein (rFc Tag)

• Home
• Products
• Fusion Proteins
• AuthentiKine ELISA Kits
• Recombinant Mouse NKG2C/CD159c protein (rFc Tag) (Eg1505)

Species

Mouse

Purity

>90 %, SDS-PAGE

Tag

rFc Tag

Activity

not tested

Cat no : Eg1505

---

Validation Data Gallery

• 

  Purity of Recombinant Mouse NKG2C was determined by SDS-PAGE. The protein was resolved in an SDS-PAGE in reducing (R) conditions and stained using Coomassie blue.

---

Product Information

• Purity: >90 %, SDS-PAGE
• Endotoxin: <0.1 EU/μg protein, LAL method
• Activity:

  Not tested

• Expression: HEK293-derived Mouse NKG2C protein Ser89-Ile238 (Accession# Q9WTJ9) with a rabbit IgG Fc tag at the N-terminus.
• GeneID: 16642
• Accession: Q9WTJ9
• PredictedSize: 44.2 kDa
• SDS-PAGE: 48-68 kDa, reducing (R) conditions
• Formulation: Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization.
• Reconstitution: Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water.
• Storage Conditions:
  It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
  • Until expiry date, -20℃ to -80℃ as lyophilized proteins.
  • 3 months, -20℃ to -80℃ under sterile conditions after reconstitution.
• Shipping: The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature.

Background

NKG2-C type II integral membrane protein (NKG2C) is also named CD159c. NKG2C regulates the effector functions of terminally differentiated cytotoxic lymphocyte subsets, and in particular may play a role in adaptive NK cell response to viral infection (PMID:20952657, PMID:21825173). Upon HLA-E-peptide binding, NKG2C transmits intracellular signals via the adapter protein TYROBP/DAP12, triggering the phosphorylation of proximal signaling molecules and cell activation (PMID:15940674, PMID:9655483).

References:

1.Angelini DF, et al. (2011) J Leukoc Biol. 89(1):75-84.
2.Lopez-Vergès S, et al. (2011) Proc Natl Acad Sci U S A. 108(36):14725-32.
3.Gumá M, et al. (et al) Eur J Immunol. 35(7):2071-80.
4.Lanier LL, et al. (1998) Immunity. 8(6):693-701.