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Recombinant Mouse NKp46/NCR1 protein (rFc Tag)

Species

Mouse

Purity

>90 %, SDS-PAGE

Tag

rFc Tag

Activity

not tested

Cat no : Eg1825

Validation Data Gallery

  • Purity of Recombinant Mouse NKp46 was determined by SDS-PAGE. The protein was resolved in an SDS-PAGE in reducing (R) and non-reducing (NR) conditions and stained using Coomassie blue.

    Purity of Recombinant Mouse NKp46 was determined by SDS-PAGE. The protein was resolved in an SDS-PAGE in reducing (R) and non-reducing (NR) conditions and stained using Coomassie blue.

Product Information

Purity >90 %, SDS-PAGE
Endotoxin <0.1 EU/μg protein, LAL method
Activity 
Not tested
Expression HEK293-derived Mouse NKp46 protein Gln17-Asn255 (Accession# Q8C567) with a rabbit IgG Fc tag at the C-terminus.
GeneID 17086
Accession Q8C567
PredictedSize 53.4 kDa
SDS-PAGE 60-70 kDa, reducing (R) conditions
Formulation Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization.
Reconstitution Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water.
Storage Conditions
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
  • Until expiry date, -20℃ to -80℃ as lyophilized proteins.
  • 3 months, -20℃ to -80℃ under sterile conditions after reconstitution.
Shipping The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature.

Background

NKp46, also known as NCR1 or CD335, is an Ig-like superfamily cell surface receptor that is highly conserved in mammals. NKp46 is a type I transmembrane glycoprotein consisting of two extracellular Ig-like domains, a transmembrane domain, and an intracellular tail. It is expressed on NK cells, rare T-cell subsets and a mucosal population of NKp46+ innate lymphoid cells. NKp46 is the major triggering receptor involved in the natural cytotoxicity.

References:

1.Narni-Mancinelli E, et al. (2011) Proc Natl Acad Sci U S A. 108(45):18324-9.
2.Pessino A, et al. (1998) J Exp Med. 188(5):953-60.
3.Narni-Mancinelli E, et al. (2011) Proc Natl Acad Sci U S A. 108(45):18324-9.
4.Sivori S, et al. (1999) Eur J Immunol. 29(5):1656-66.
5.Biassoni R, et al. (1999) Eur J Immunol. 29(3):1014-20.
6.Westgaard IH, et al. (2004) J Leukoc Biol. 76(6):1200-6.