Recombinant Mouse TREML2 protein (rFc Tag)

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• Recombinant Mouse TREML2 protein (rFc Tag) (Eg7510)

Species

Mouse

Purity

>90 %, SDS-PAGE

Tag

rFc Tag

Activity

not tested

Cat no : Eg7510

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Validation Data Gallery

• 

  Purity of Recombinant Mouse TREML2 was determined by SDS-PAGE. The protein was resolved in an SDS-PAGE in reducing (R) and non-reducing (NR) conditions and stained using Coomassie blue.

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Product Information

• Purity: >90 %, SDS-PAGE
• Endotoxin: <0.1 EU/μg protein, LAL method
• Activity:

  Not tested

• Expression: HEK293-derived Mouse TREML2 protein His25-Ala270 (Accession# Q2LA85) with a rabbit IgG Fc tag at the C-terminus.
• GeneID: 328833
• Accession: Q2LA85
• PredictedSize: 53.1 kDa
• SDS-PAGE: 80-100 kDa, reducing (R) conditions
• Formulation: Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization.
• Reconstitution: Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water.
• Storage Conditions:
  It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
  • Until expiry date, -20℃ to -80℃ as lyophilized proteins.
  • 3 months, -20℃ to -80℃ under sterile conditions after reconstitution.
• Shipping: The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature.

Background

Triggering receptor expressed on myeloid cells-like protein 2 (TREML2) is a cell-surface receptor participating in innate and adaptive immune responses. It functions as a counter-receptor for CD276, and its binding to CD276 on T cells potentiates T-cell activation. Upregulating TREML2 represents a potential novel therapeutic strategy to alleviate doxorubicin resistance in acute myeloid leukemia.

References:

1. Allcock, Richard J N et al. European journal of immunology vol. 33,2 (2003): 567-77.
2. Hashiguchi, Masaaki et al. Proceedings of the National Academy of Sciences of the United States of America vol. 105,30 (2008): 10495-500.
3. Zhang, Xin et al. Blood science (Baltimore, Md.) vol. 7,2 (2025): e00223.