Recombinant Mouse TYRO3 protein (rFc Tag)

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• Recombinant Mouse TYRO3 protein (rFc Tag) (Eg2918)

Species

Mouse

Purity

>90 %, SDS-PAGE

Tag

rFc Tag

Activity

not tested

Cat no : Eg2918

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Validation Data Gallery

• 

  Purity of Recombinant Mouse TYRO3 was determined by SDS-PAGE. The protein was resolved in an SDS-PAGE in reducing (R) conditions and stained using Coomassie blue.

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Product Information

• Purity: >90 %, SDS-PAGE
• Endotoxin: <0.1 EU/μg protein, LAL method
• Activity:

  Not tested

• Expression: HEK293-derived Mouse TYRO3 protein Ala31-Ser418 (Accession# P55144-1) with a rabbit IgG Fc tag at the C-terminus.
• GeneID: 22174
• Accession: P55144-1
• PredictedSize: 67.8 kDa
• SDS-PAGE: 75-100 kDa, reducing (R) conditions
• Formulation: Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization.
• Reconstitution: Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water.
• Storage Conditions:
  It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
  • Until expiry date, -20℃ to -80℃ as lyophilized proteins.
  • 3 months, -20℃ to -80℃ under sterile conditions after reconstitution.
• Shipping: The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature.

Background

TYRO3 has a structure includes a cytoplasmic domain and an extracellular ligand binding region. And ligand binding at the cell surface induces dimerization and autophosphorylation of TYRO3 on its intracellular domain that provides docking sites for downstream signaling molecules. TYRO3 is associated with many physiological processes including cell survival, migration and differentiation. It has been reported that TYRO3 can be expressed in various regions of the mammalian central nervous system.

References:

1. Tomobe YI. et al, (1996) Neurosci Lett. 214(1):57-60. 
2. Pierce A. et al. (2011) Mol Cell Endocrinol. 339(1-2):151-8.