NEDD4 Recombinant antibody, PBS Only

NEDD4 Recombinant Antibody for WB, IP, Indirect ELISA

Host / Isotype

Rabbit / IgG


Human, Mouse, Rat


WB, IP, Indirect ELISA





Cat no : 83112-1-PBS


KIAA0093, NEDD 4, NEDD4, NEDD4 1, RPF1

Recommended dilution

It is recommended that this reagent should be titrated in each testing system to obtain optimal results.

Product Information

83112-1-PBS targets NEDD4 in WB, IP, Indirect ELISA applications and shows reactivity with Human, Mouse, Rat samples.

Tested Reactivity Human, Mouse, Rat
Host / Isotype Rabbit / IgG
Class Recombinant
Type Antibody
Immunogen NEDD4 fusion protein Ag16291
Full Name neural precursor cell expressed, developmentally down-regulated 4
Calculated Molecular Weight 1319 aa, 149 kDa
Observed Molecular Weight 115 kDa
GenBank Accession NumberBC152452
Gene Symbol NEDD4
Gene ID (NCBI) 4734
Conjugate Unconjugated
Form Liquid
Purification MethodProtein A purification
Storage Buffer PBS Only
Storage ConditionsStore at -80°C.

Background Information

NEDD4 and similar proteins discovered subsequently became a family of HECT ligases, comprising 9 human proteins including NEDD4, NEDD4-2 (NEDD4L), ITCH, SMURF1, SMURF2, WWP1, WWP2, NEDL1 and NEDL2. NEDD4 is a highly evolutionarily conserved protein from yeast to man, and was initially cloned as a highly expressed gene in the early embryonic brain. NEDD4 is frequently overexpressed in many different types of cancer, and decreased levels of NEDD4 can also be associated with cancer. It can be a potential therapeutic target for the treatment of human cancer.(PMID: 25527121). The human NEDD4 gene is located on chromosome 15q21.3 and comprises 30 exons (HGNC:7727) shown to encode a ~120 KDa protein. Otherwise there is a 75 kDa isoform in addition to full length NEDD4 (PMID: 24907641).