Anti-Human NGFR/TNFRSF16 Rabbit Recombinant Antibody

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• Anti-Human NGFR/TNFRSF16 Rabbit Recombinant Antibody (98896-5-RR)

NGFR/TNFRSF16 Uni-rAb^® Recombinant Antibody for FC

Cat No. 98896-5-RR

Clone No.260065A1

Host / Isotype

Rabbit / IgG

Reactivity

human

Applications

FC

Synonyms

NGFR, CD271, Gp80 LNGFR, Gp80-LNGFR, Low-affinity nerve growth factor receptor

• 

  FC experiment of SK-N-SH using 98896-5-RR

  1x10^6 SK-N-SH cells were surface stained with 0.25 ug Anti-Human NGFR/TNFRSF16 Rabbit RecAb (98896-5-RR, Clone: 260065A1) (red) or Rabbit IgG Isotype Control Recombinant Antibody (98136-1-RR, Clone: 240953C9) (blue), and PE-Conjugated Goat Anti-Rabbit IgG(H+L). Cells were not fixed.

  This validation data has been generated in-house and reviewed by Proteintech scientists. Find out more on our antibody validation policy
• 

  FC experiment of Transfected CHO-K1 using 98896-5-RR

  1x10^6 CHO-K1 (left) or NGFR/TNFRSF16 transfected CHO-K1 (right) or were surface stained with 0.25 ug Anti-Human NGFR/TNFRSF16 Rabbit RecAb (98896-5-RR, Clone: 260065A1) and PE-Conjugated Goat Anti-Rabbit IgG(H+L). Cells were not fixed.

  This validation data has been generated in-house and reviewed by Proteintech scientists. Find out more on our antibody validation policy
• 

  FC experiment of Transfected CHO-K1 using 98896-5-RR

  1x10^6 CHO-K1 (left) or NGFR/TNFRSF16 transfected CHO-K1 (right) were surface stained with 0.25 ug Anti-Human NGFR/TNFRSF16 Rabbit RecAb (98896-5-RR, Clone: 260065A1) (red) or Rabbit IgG Isotype Control Recombinant Antibody (98136-1-RR, Clone: 240953C9) (blue), and PE-Conjugated Goat Anti-Rabbit IgG(H+L). Cells were not fixed.

  This validation data has been generated in-house and reviewed by Proteintech scientists. Find out more on our antibody validation policy

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Tested Applications

• Positive FC detected in: SK-N-SH cells, Transfected CHO-K1 cells

Recommended dilution

• Flow Cytometry (FC): FC : 0.25 ug per 10^6 cells in a 100 µl suspension

This reagent has been tested for flow cytometric analysis. It is recommended that this reagent should be titrated in each testing system to obtain optimal results.

Sample-dependent, Check data in validation data gallery.

Product Information

98896-5-RR targets NGFR/TNFRSF16 in FC applications and shows reactivity with human samples.

• Tested Reactivity: human
• Host / Isotype: Rabbit / IgG
• Class: Recombinant
• Type: Antibody
• Immunogen:

  CatNo: Eg4829

  Product name: Recombinant Human NGFR/TNFRSF16 protein (rFc Tag)(HPLC verified)

  Source: mammalian cells-derived, pHZ-KIsec-C-rFc

  Tag: C-rFc

  Domain: 29-250 aa of NM_002507.4

  Sequence: KEACPTGLYTHSGECCKACNLGEGVAQPCGANQTVCEPCLDSVTFSDVVSATEPCKPCTECVGLQSMSAPCVEADDAVCRCAYGYYQDETTGRCEACRVCEAGSGLVFSCQDKQNTVCEECPDGTYSDEANHVDPCLPCTVCEDTERQLRECTRWADAECEEIPGRWITRSTPPEGSDSTAPSTQEPEAPPEQDLIASTVAGVVTTVMGSSQPVVTRGTTDN

• Full Name: nerve growth factor receptor (TNFR superfamily, member 16)
• Calculated Molecular Weight: 45 kDa
• GenBank Accession Number: NM_002507.4
• Gene Symbol: p75NTR
• Gene ID (NCBI): 4804
• Conjugate: Unconjugated
• Form: Liquid
• Purification Method: Protein A purification
• UNIPROT ID: P08138-1
• Storage Buffer: PBS with 0.09% sodium azide, pH 7.3.
• Storage Conditions: Store at 2 - 8°C. Stable for one year after shipment.

Background Information

The nerve growth factor (NGF) receptor (NGFR), also known as p75NTR, TNFRSF16, belongs to the tumor necrosis factor receptor superfamily, which is a low-affinity receptor of neurotrophins including NGF, brain-derived neurotrophic factor (BDNF), and neurotrophin-3, -4, and -5. It is now apparent that expression of NGFR is ubiquitous and not limited to the nervous system, being expressed in mature non-neural cells such as perivascular cells, dental pulp cells, lymphoidal follicular dendritic cells, basal epithelium of oral mucosa and hair follicles, prostate basal cells and myoepithelial cells (PMID: 38307025, 16424897).