CoraLite® Plus 488 Anti-Human NGFR/TNFRSF16 Rabbit Recombinant Antibody

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• CoraLite® Plus 488 Anti-Human NGFR/TNFRSF16 Rabbit Recombinant Antibody (CL488-98896-5)

NGFR/TNFRSF16 Uni-rAb^® Recombinant Antibody for FC

Cat No. CL488-98896-5

Clone No.260065A1

Host / Isotype

Rabbit / IgG

Reactivity

human

Applications

FC

Synonyms

NGFR, CD271, Gp80 LNGFR, Gp80-LNGFR, Low-affinity nerve growth factor receptor

• 

  FC experiment of SK-N-SH using CL488-98896-5

  1x10^6 SK-N-SH cells were surface stained with 5 ul CoraLite® Plus 488 Anti-Human NGFR/TNFRSF16 Rabbit RecAb (CL488-98896-5, Clone: 260065A1) (red) or CoraLite® Plus 488 Rabbit IgG Isotype Control Recombinant Antibody (CL488-98136, Clone: 240953C9) (blue). Cells were not fixed.

  This validation data has been generated in-house and reviewed by Proteintech scientists. Find out more on our antibody validation policy

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Tested Applications

• Positive FC detected in: SK-N-SH cells

Recommended dilution

• Flow Cytometry (FC): FC : 5 ul per 10^6 cells in a 100 µl suspension

This reagent has been pre-titrated and tested for flow cytometric analysis. The suggested use of this reagent is 5 ul per 10^6 cells in a 100 µl suspension or 5 ul per 100 µl of whole blood.

Sample-dependent, Check data in validation data gallery.

Product Information

CL488-98896-5 targets NGFR/TNFRSF16 in FC applications and shows reactivity with human samples.

• Tested Reactivity: human
• Host / Isotype: Rabbit / IgG
• Class: Recombinant
• Type: Antibody
• Immunogen:

  CatNo: Eg4829

  Product name: Recombinant Human NGFR/TNFRSF16 protein (rFc Tag)(HPLC verified)

  Source: mammalian cells-derived, pHZ-KIsec-C-rFc

  Tag: C-rFc

  Domain: 29-250 aa of NM_002507.4

  Sequence: KEACPTGLYTHSGECCKACNLGEGVAQPCGANQTVCEPCLDSVTFSDVVSATEPCKPCTECVGLQSMSAPCVEADDAVCRCAYGYYQDETTGRCEACRVCEAGSGLVFSCQDKQNTVCEECPDGTYSDEANHVDPCLPCTVCEDTERQLRECTRWADAECEEIPGRWITRSTPPEGSDSTAPSTQEPEAPPEQDLIASTVAGVVTTVMGSSQPVVTRGTTDN

• Full Name: nerve growth factor receptor (TNFR superfamily, member 16)
• Calculated Molecular Weight: 45 kDa
• GenBank Accession Number: NM_002507.4
• Gene Symbol: p75NTR
• Gene ID (NCBI): 4804
• Conjugate: CoraLite® Plus 488 Fluorescent Dye
• Excitation/Emission Maxima Wavelengths: 493 nm / 522 nm
• Form: Liquid
• Purification Method: Protein A purification
• UNIPROT ID: P08138-1
• Storage Buffer: PBS with 0.09% sodium azide and 0.5% BSA, pH 7.3.
• Storage Conditions: Store at 2-8°C. Avoid exposure to light. Stable for one year after shipment.

Background Information

The nerve growth factor (NGF) receptor (NGFR), also known as p75NTR, TNFRSF16, belongs to the tumor necrosis factor receptor superfamily, which is a low-affinity receptor of neurotrophins including NGF, brain-derived neurotrophic factor (BDNF), and neurotrophin-3, -4, and -5. It is now apparent that expression of NGFR is ubiquitous and not limited to the nervous system, being expressed in mature non-neural cells such as perivascular cells, dental pulp cells, lymphoidal follicular dendritic cells, basal epithelium of oral mucosa and hair follicles, prostate basal cells and myoepithelial cells (PMID: 38307025, 16424897).