NeutraControl PDGF-BB Monoclonal antibody
NeutraControl PDGF-BB Monoclonal Antibody for Non-Neutralization, ELISA
Cat no : 69520-1-Ig
69520-1-Ig targets PDGF-BB in Non-Neutralization, ELISA applications and shows reactivity with Human samples.
|Host / Isotype||Mouse / IgG2a|
|Immunogen||human Humankine PDGF-BB protein HZ-1308|
|Full Name||platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog)|
|Gene ID (NCBI)||5155|
|Purification Method||Protein A purification|
|Storage Buffer||Sterile PBS.|
|Reconstitution||This product was lyophilized from a 0.2 μm filtered solution in PBS. Reconstitute at 1.0 mg/mL in sterile H2O before use.|
|Stability and Storage||Lyophilized antibodies are stable for 1 year from the date of receipt if stored between (-20°C) and (-80°C). Upon reconstitution we recommend that the solution can be stored at (4°C) for short term or at (-20°C) to (-80°C) for long term. Repeated freeze thaw cycles should be avoided with reconstituted products.|
Platelet-derived growth factor (PDGF) belongs to the family of growth factors consisting of four secreted extracellular ligands including PDGF-A, -B, -C and -D. These isoforms, PDGF-AA, PDGF-AB, PDGF-BB, PDGF-CC and PDGF-DD, act via two receptor tyrosine kinases, PDGF receptors alpha and beta. PDGF isoforms stimulate growth, survival and motility of mesenchymal cells and certain other cell type. They have important functions during embryonal development and in the control of tissue homeostasis in the adult. PDGF-BB is one of the most recently studied isoforms and it plays an important role in skeletal development. PDGF-BB stimulates cell-mediated collagen gel contraction. PDGF-BB modulates endothelial proliferation and angiogenesis in vitro via PDGF beta-receptors.
This antibody is a neutralizing control antibody for PDGF-BB, the immunogen is the same as Neutrakine 69020-1-Ig but could not neutralize human PDGF-BB.