Product Information
69002-1-PBS targets NeutraKine® TNF-alpha in Neutralization, ELISA applications and shows reactivity with human, mouse samples.
Tested Reactivity | human, mouse |
Host / Isotype | Mouse / IgG1 |
Class | Monoclonal |
Type | Antibody |
Immunogen | human Humankine TNF-alpha protein HZ-1014 Predict reactive species |
Full Name | tumor necrosis factor (TNF superfamily, member 2) |
Gene Symbol | TNF-alpha |
Gene ID (NCBI) | 7124 |
ENSEMBL Gene ID | ENSG00000232810 |
RRID | AB_2882920 |
Conjugate | Unconjugated |
Purification Method | Protein G purification |
Storage Buffer | PBS only, pH 7.3. |
Storage Conditions | Store at -80°C. |
Background Information
TNF, as also known as TNF-alpha, or cachectin, is a multifunctional proinflammatory cytokine that belongs to the tumor necrosis factor (TNF) superfamily. It is expressed as a 26 kDa membrane bound protein and is then cleaved by TNF-alpha converting enzyme (TACE) to release the soluble 17 kDa monomer, which forms homotrimers in circulation. It is produced chiefly by activated macrophages, although it can be produced by many other cell types such as CD4+ lymphocytes, NK cells, neutrophils, mast cells, eosinophils, and neurons. It can bind to, and thus functions through its receptors TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. This cytokine is involved in the regulation of a wide spectrum of biological processes including cell proliferation, differentiation, apoptosis, lipid metabolism, and coagulation. This cytokine has been implicated in a variety of diseases, including autoimmune diseases, INS resistance, and cancer.
This antibody can be used to neutralize the bioactivity of TNF alpha.