Product Information
33794-1-PBS targets OTOG in WB, Indirect ELISA applications and shows reactivity with human samples.
| Tested Reactivity | human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen |
CatNo: Eg5591 Product name: Recombinant human OTOG protein Source: mammalian cells-derived, V37 Tag: C-rFc Domain: 1634-1796 aa of NM_001277269.2 Sequence: VRGHGSLPVRTTPPQPSLTASPSSRPVASPGAISRSPTSSGSHKAVLTPAVTKVISRTGVPQPTQAQSASSPSTPLTVAGTAAEQVPVSPLATRSLEIVLSTEKGEAGHSQPMGSPASPQPHPLPSAPPRPAQHTTMATRSPALPPETPAAASLSTATDGLAA Predict reactive species |
| Full Name | otogelin |
| Calculated Molecular Weight | 315 kDa |
| Observed Molecular Weight | 314 kDa |
| GenBank Accession Number | NM_001277269.2 |
| Gene Symbol | OTOG |
| Gene ID (NCBI) | 340990 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification Method | Antigen affinity Purification |
| UNIPROT ID | Q6ZRI0-1 |
| Storage Buffer | PBS only, pH 7.3. |
| Storage Conditions | Store at -80°C. |
Background Information
OTOG (Otogelin) is a glycoprotein that is highly expressed in the inner ear and is essential for maintaining hearing and balance functions. It belongs to the mucin-like glycoprotein family and is a large extracellular matrix protein with numerous glycosylation sites. This allows it to form gel-like structures that provide structural support during mechanical transduction in the inner ear. Mutations or loss of function in the OTOG gene can lead to severe hereditary deafness and vestibular dysfunction. There are two isoforms of OTOG, with molecular weights of 160 kDa and 314 kDa respectively.
