PACS2-Specific Polyclonal antibody

• Featured Product
• KD/KO Validated

PACS2-Specific Polyclonal Antibody for ELISA

Host / Isotype

Rabbit / IgG

Reactivity

human, mouse, rat

Applications

WB, IHC, IF, IP, ELISA

Conjugate

Unconjugated

Publications

19

Cat no : 19508-1-AP

Synonyms

PACS2, PACS-2, PACS1-like protein, PACS1L, PACS 2

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Validation Data Gallery

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Published Applications

• KD/KO: See 5 publications below
• WB: See 17 publications below
• IHC: See 2 publications below
• IF: See 6 publications below
• IP: See 3 publications below

Product Information

19508-1-AP targets PACS2-Specific in WB, IHC, IF, IP, ELISA applications and shows reactivity with human, mouse, rat samples.

• Tested Reactivity: human, mouse, rat
• Cited Reactivity: human, mouse, rat
• Host / Isotype: Rabbit / IgG
• Class: Polyclonal
• Type: Antibody
• Immunogen: Peptide
• Full Name: phosphofurin acidic cluster sorting protein 2
• Calculated Molecular Weight: 98 kDa
• Observed Molecular Weight: 116 kDa
• GenBank Accession Number: NM_015197
• Gene Symbol: PACS2
• Gene ID (NCBI): 23241
• RRID: AB_10643387
• Conjugate: Unconjugated
• Form: Liquid
• Purification Method: Antigen affinity purification
• Storage Buffer: PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
• Storage Conditions: Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20^oC storage. 20ul sizes contain 0.1% BSA.

Background Information

PACS2, also named PACS1L or KIAA0602, is one of PACS (phosphofurin acidic cluster sorting) proteins which are one such family of multifunctional membrane traffic regulators that mediate organ homoeostasis and have important roles in diverse pathologies and disease states. PACS2 is a multifunctional sorting protein that controls the endoplasmic reticulum (ER)-mitochondria communication, ER homeostasis, and apoptosis. PACS2 may be involved in ion channel trafficking, directing acidic cluster-containing ion channels to distinct subcellular compartments.

Publications

Species	Application	Title
human	WB	Nature; Autophagosomes form at ER-mitochondria contact sites.; Authors - Hamasaki Maho M
mouse	WB	Circulation; Hyperglycemia-Driven Inhibition of AMP-Activated Protein Kinase α2 Induces Diabetic Cardiomyopathy by Promoting Mitochondria-Associated Endoplasmic Reticulum Membranes In Vivo.; Authors - Shengnan Wu
human	WB	EMBO J; MITOL prevents ER stress-induced apoptosis by IRE1α ubiquitylation at ER-mitochondria contact sites.; Authors - Keisuke Takeda ; KD Validated
human, mouse	WB, IF, IP	Nat Commun; The sorting protein PACS-2 promotes ErbB signalling by regulating recycling of the metalloproteinase ADAM17.; Authors - Sarah Louise Dombernowsky ; KD Validated
human	WB	EMBO J; MITOL prevents ER stress-induced apoptosis by IRE1α ubiquitylation at ER-mitochondria contact sites.; Authors - Keisuke Takeda ; KD Validated
human,mouse	WB,IF,IP	Diabetes; PACS-2 Ameliorates Tubular Injury by Facilitating Endoplasmic Reticulum-Mitochondria Contact and Mitophagy in Diabetic Nephropathy.; Authors - Chenrui Li