PAPP A2 Polyclonal antibody, PBS Only

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• PAPP A2 Polyclonal antibody, PBS Only (33013-1-PBS)

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  WB analysis using 33013-1-AP (same clone as 33013-1-PBS)

  Human placenta tissue were subjected to SDS PAGE followed by western blot with 33013-1-AP (PAPP A2 antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 33013-1-PBS in a different storage buffer formulation.

PAPP A2 Polyclonal Antibody for WB, Indirect ELISA

Cat No. 33013-1-PBS

Host / Isotype

Rabbit / IgG

Reactivity

human

Applications

WB, Indirect ELISA

Synonyms

PAPPA2, PAPP E, pappalysin 2, PAPPE, PLAC3

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Product Information

33013-1-PBS targets PAPP A2 in WB, Indirect ELISA applications and shows reactivity with human samples.

• Tested Reactivity: human
• Host / Isotype: Rabbit / IgG
• Class: Polyclonal
• Type: Antibody
• Immunogen:

  CatNo: Eg2812

  Product name: Recombinant Human PAPPA2 protein (rFc Tag)

  Source: mammalian cells-derived, V37

  Tag: C-rFc

  Domain: 234-1396 aa of NM_020318.2

  Sequence: SPPEESNQNGGEGSYREAETFNSQVGLPILYFSGRRERLLLRPEVLAEIPREAFTVEAWVKPEGGQNNPAIIAGVFDNCSHTVSDKGWALGIRSGKDKGKRDARFFFSLCTDRVKKATILISHSRYQPGTWTHVAATYDGRHMALYVDGTQVASSLDQSGPLNSPFMASCRSLLLGGDSSEDGHYFRGHLGTLVFWSTALPQSHFQHSSQHSSGEEEATDLVLTASFEPVNTEWVPFRDEKYPRLEVLQGFEPEPEILSPLQPPLCGQTVCDNVELISQYNGYWPLRGEKVIRYQVVNICDDEGLNPIVSEEQIRLQHEALNEAFSRYNISWQLSVHQVHNSTLRHRVVLVNCEPSKIGNDHCDPECEHPLTGYDGGDCRLQGRCYSWNRRDGLCHVECNNMLNDFDDGDCCDPQVADVRKTCFDPDSPKRAYMSVKELKEALQLNSTHFLNIYFASSVREDLAGAATWPWDKDAVTHLGGIVLSPAYYGMPGHTDTMIHEVGHVLGLYHVFKGVSERESCNDPCKETVPSMETGDLCADTAPTPKSELCREPEPTSDTCGFTRFPGAPFTNYMSYTDDNCTDNFTPNQVARMHCYLDLVYQQWTESRKPTPIPIPPMVIGQTNKSLTIHWLPPISGVVYDRASGSLCGACTEDGTFRQYVHTASSRRVCDSSGYWTPEEAVGPPDVDQPCEPSLQAWSPEVHLYHMNMTVPCPTEGCSLELLFQHPVQADTLTLWVTSFFMESSQVLFDTEILLENKESVHLGPLDTFCDIPLTIKLHVDGKVSGVKVYTFDERIEIDAALLTSQPHSPLCSGCRPVRYQVLRDPPFASGLPVVVTHSHRKFTDVEVTPGQMYQYQVLAEAGGELGEASPPLNHIHGAPYCGDGKVSERLGEECDDGDLVSGDGCSKVCELEEGFNCVGEPSLCYMYEGDGICEPFERKTSIVDCGIYTPKGYLDQWATRAYSSHEDKKKCPVSLVTGEPHSLICTSYHPDLPNHRPLTGWFPCVASENETQDDRSEQPEGSLKKEDEVWLKVCFNRPGEARAIFIFLTTDGLVPGEHQQPTVTLYLTDVRGSNHSLGTYGLSCQHNPLIINVTHHQNVLFHHTTSVLLNFSSPRVGISAVALRTSSRIGLSAPSNCISEDEGQNHQGQSCIHRPCGKQDSC

• Full Name: pappalysin 2
• Calculated Molecular Weight: 199 kDa
• Observed Molecular Weight: 250 kDa
• GenBank Accession Number: NM_020318.2
• Gene Symbol: PAPPA2
• Gene ID (NCBI): 60676
• RRID: AB_3742821
• Conjugate: Unconjugated
• Form: Liquid
• Purification Method: Antigen affinity Purification
• UNIPROT ID: Q9BXP8-1
• Storage Buffer: PBS only, pH 7.3.
• Storage Conditions: Store at -80°C.

Background Information

PAPP A2 (Pregnancy-associated Plasma Protein A2) is a metalloproteinase member of the PAPP A protein family and is mainly secreted by the syncytiotrophoblast cells of the placenta. Unlike PAPP A in the same family that regulates the biological activity of insulin-like growth factors (IGFs), PAPP A2 can specifically cleave and inactivate the IGF-binding protein 5 (IGFBP-5), thereby releasing more free IGFs to promote fetal development. Moreover, its concentration significantly increases in the maternal blood during pregnancy, making it a potential new biomarker for assessing placental function and fetal growth restriction.