CoraLite® Plus 488 Anti-Human PD-L1 (B7-H1) (29E.2A3)
PD-L1 (B7-H1) Monoclonal Antibody for FC
Host / Isotype
Mouse / IgG2b, kappa
CoraLite® Plus 488 Fluorescent Dye
Cat no : CL488-65081
|Positive FC detected in
|PHA treated human PBMCs
|This reagent has been pre-titrated and tested for flow cytometric analysis. The suggested use of this reagent is 5 µl per 10^6 cells in a 100 µl suspension or 5 µl per 100 µl of whole blood.
|Sample-dependent, check data in validation data gallery
CL488-65081 targets PD-L1 (B7-H1) in FC applications and shows reactivity with Human samples.
|Host / Isotype
|Mouse / IgG2b, kappa
|Full length human PD-L1
|GenBank accession number
|Gene ID (NCBI)
|CoraLite® Plus 488 Fluorescent Dye
|Excitation/Emission maxima wavelengths
|493 nm / 522 nm
|PBS with 0.1% sodium azide and 0.5% BSA, pH 7.3.
|Store at 2-8°C. Avoid exposure to light. Stable for one year after shipment.
Programmed cell death ligand 1 (PD-L1, CD274, or B7-H1), is the first member of B7 family to be discovered. B7 family molecules are type I transmembrane proteins belonging to the immunoglobulin superfamily. In concert with their CD28 family receptors, the B7s are key regulators of the adaptive immune response. PD-L1 is suggested as a negative regulator of T and B cell, and plays important role in mediating tolerance of lymphocytes to self-antigens. It is also involved in the costimulatory signal, essential for T-cell proliferation and production of IL10 and IFNG, in an IL2-dependent and a PD-1-independent manner.