PDE11A Polyclonal antibody

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• PDE11A Polyclonal antibody (24287-1-AP)

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  WB analysis using 24287-1-AP

  Various lysates were subjected to SDS PAGE followed by western blot with 24287-1-AP (PDE11A antibody) at dilution of 1:600 incubated at room temperature for 1.5 hours.

PDE11A Polyclonal Antibody for WB, ELISA

Cat No. 24287-1-AP

Host / Isotype

Rabbit / IgG

Reactivity

human, mouse, rat

Applications

WB, ELISA

Synonyms

phosphodiesterase 11A, PPNAD2

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Tested Applications

• Positive WB detected in: mouse cerebellum tissue, mouse liver tissue, rat liver tissue

Recommended dilution

• Western Blot (WB): WB : 1:500-1:1000

It is recommended that this reagent should be titrated in each testing system to obtain optimal results.

Sample-dependent, Check data in validation data gallery.

Product Information

24287-1-AP targets PDE11A in WB, ELISA applications and shows reactivity with human, mouse, rat samples.

• Tested Reactivity: human, mouse, rat
• Host / Isotype: Rabbit / IgG
• Class: Polyclonal
• Type: Antibody
• Immunogen:

  CatNo: Ag16495

  Product name: Recombinant human PDE11A protein

  Source: e coli.-derived, PET28a

  Tag: 6*His

  Domain: 582-934 aa of BC114431

  Sequence: SYHATCSKAEVDKFKAANIPLVSELAIDDIHFDDFSLDVDAMITAALRMFMELGMVQKFKIDYETLCRWLLTVRKNYRMVLYHNWRHAFNVCQLMFAMLTTAGFQDILTEVEILAVIVGCLCHDLDHRGTNNAFQAKSGSALAQLYGTSATLEHHHFNHAVMILQSEGHNIFANLSSKEYSDLMQLLKQSILATDLTLYFERRTEFFELVSKGEYDWNIKNHRDIFRSMLMTACDLGAVTKPWEISRQVAELVTSEFFEQGDRERLELKLTPSAIFDRNRKDELPRLQLEWIDSICMPLYQALVKVNVKLKPMLDSVATNRSKWEELHQKRLLASTASSSSPASVMVAKEDRN

• Full Name: phosphodiesterase 11A
• Calculated Molecular Weight: 934 aa, 105 kDa
• Observed Molecular Weight: 66 kDa
• GenBank Accession Number: BC114431
• Gene Symbol: PDE11A
• Gene ID (NCBI): 50940
• RRID: AB_3742105
• Conjugate: Unconjugated
• Form: Liquid
• Purification Method: Antigen affinity purification
• UNIPROT ID: Q9HCR9
• Storage Buffer: PBS with 0.02% sodium azide and 50% glycerol, pH 7.3.
• Storage Conditions: Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20^oC storage. 20ul sizes contain 0.1% BSA.

Background Information

PDE11A is a dual-specificity cyclic nucleotide phosphodiesterase that regulates cAMP and cGMP signaling in a tissue-restricted manner, with prominent roles in the endocrine system and brain. By shaping compartmentalized second-messenger signaling, PDE11A controls steroidogenesis, neuronal plasticity, and hormone responsiveness. Genetic alterations in PDE11A underlie adrenal hyperplasia, endocrine dysfunction, and neuropsychiatric phenotypes, highlighting its importance in cyclic nucleotide homeostasis.