Product Information
24287-1-PBS targets PDE11A in WB, Indirect ELISA applications and shows reactivity with human, mouse, rat samples.
| Tested Reactivity | human, mouse, rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen |
CatNo: Ag16495 Product name: Recombinant human PDE11A protein Source: e coli.-derived, PET28a Tag: 6*His Domain: 582-934 aa of BC114431 Sequence: SYHATCSKAEVDKFKAANIPLVSELAIDDIHFDDFSLDVDAMITAALRMFMELGMVQKFKIDYETLCRWLLTVRKNYRMVLYHNWRHAFNVCQLMFAMLTTAGFQDILTEVEILAVIVGCLCHDLDHRGTNNAFQAKSGSALAQLYGTSATLEHHHFNHAVMILQSEGHNIFANLSSKEYSDLMQLLKQSILATDLTLYFERRTEFFELVSKGEYDWNIKNHRDIFRSMLMTACDLGAVTKPWEISRQVAELVTSEFFEQGDRERLELKLTPSAIFDRNRKDELPRLQLEWIDSICMPLYQALVKVNVKLKPMLDSVATNRSKWEELHQKRLLASTASSSSPASVMVAKEDRN Predict reactive species |
| Full Name | phosphodiesterase 11A |
| Calculated Molecular Weight | 934 aa, 105 kDa |
| Observed Molecular Weight | 66 kDa |
| GenBank Accession Number | BC114431 |
| Gene Symbol | PDE11A |
| Gene ID (NCBI) | 50940 |
| RRID | AB_3742105 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification Method | Antigen affinity purification |
| UNIPROT ID | Q9HCR9 |
| Storage Buffer | PBS only, pH 7.3. |
| Storage Conditions | Store at -80°C. |
Background Information
PDE11A is a dual-specificity cyclic nucleotide phosphodiesterase that regulates cAMP and cGMP signaling in a tissue-restricted manner, with prominent roles in the endocrine system and brain. By shaping compartmentalized second-messenger signaling, PDE11A controls steroidogenesis, neuronal plasticity, and hormone responsiveness. Genetic alterations in PDE11A underlie adrenal hyperplasia, endocrine dysfunction, and neuropsychiatric phenotypes, highlighting its importance in cyclic nucleotide homeostasis.
