PDE6C Polyclonal antibody

PDE6C Polyclonal Antibody for WB, ELISA

Host / Isotype

Rabbit / IgG

Reactivity

human

Applications

WB, ELISA

Conjugate

Unconjugated

Cat no : 55183-1-AP

Synonyms

cGMP phosphodiesterase 6C, PDE6C, PDEA2

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Validation Data Gallery

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  WB analysis of Y79 using 55183-1-AP

  Y79 cells were subjected to SDS PAGE followed by western blot with 55183-1-AP (PDE6C antibody) at dilution of 1:200 incubated at room temperature for 1.5 hours.

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Tested Applications

• Positive WB detected in: Y79 cells

Recommended dilution

• Western Blot (WB): WB : 1:200-1:1000

It is recommended that this reagent should be titrated in each testing system to obtain optimal results.

Sample-dependent, Check data in validation data gallery.

Product Information

55183-1-AP targets PDE6C in WB, ELISA applications and shows reactivity with human samples.

• Tested Reactivity: human
• Host / Isotype: Rabbit / IgG
• Class: Polyclonal
• Type: Antibody
• Immunogen: Peptide
• Full Name: phosphodiesterase 6C, cGMP-specific, cone, alpha prime
• Calculated Molecular Weight: 99 kDa
• Observed Molecular Weight: 52 kDa, 99 kDa
• GenBank Accession Number: NM_006204
• Gene Symbol: PDE6C
• Gene ID (NCBI): 5146
• RRID: AB_10837359
• Conjugate: Unconjugated
• Form: Liquid
• Purification Method: Antigen affinity purification
• Storage Buffer: PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
• Storage Conditions: Store at -20°C. Aliquoting is unnecessary for -20^oC storage. 20ul sizes contain 0.1% BSA.

Background Information

PDE6C, also named as PDEA2, belongs to the cyclic nucleotide phosphodiesterase family. It catalyze the reaction: Guanosine 3',5'-cyclic phosphate + H2O = guanosine 5'-phosphate. Defects in PDE6C are the cause of cone dystrophy type 4 (COD4). Mutations in the PDE6C gene encoding the catalytic subunit of the cone photoreceptor phosphodiesterase as a cause of autosomal recessive achromatopsia.(PMID:19887631) This antibody is specific to PDE6C.