Product Information
13767-1-PBS targets PPM1H in WB, Indirect ELISA applications and shows reactivity with human, mouse, rat samples.
| Tested Reactivity | human, mouse, rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen |
CatNo: Ag4750 Product name: Recombinant human PPM1H protein Source: e coli.-derived, PGEX-4T Tag: GST Domain: 1-82 aa of BC040177 Sequence: MLTRVKSAVANFMGGIMAGSSGSEHGGGSCGGSDLPLRFPYGRPEFLGLSQDEVECSADHIARPILILKETRRLPWATGYAE Predict reactive species |
| Full Name | protein phosphatase 1H (PP2C domain containing) |
| Calculated Molecular Weight | 82 aa, 9 kDa |
| Observed Molecular Weight | 50-56 kDa |
| GenBank Accession Number | BC040177 |
| Gene Symbol | PPM1H |
| Gene ID (NCBI) | 57460 |
| RRID | AB_3741841 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification Method | Antigen affinity purification |
| UNIPROT ID | Q9ULR3 |
| Storage Buffer | PBS only, pH 7.3. |
| Storage Conditions | Store at -80°C. |
Background Information
PPM1H (Protein phosphatase 1H ) is a member of a group of 3 PPM phosphatases that have been termed the 'PPM1H subfamily. In blood cells, PPM1H is expressed at high levels in basophils and lower levels in neutrophils and is very low or not detected in most other cells including monocytes. PPM1H is localized to the Golgi and its knockdown suppresses primary cilia formation, similar to pathogenic LRRK2 (PMID: 27599670, 31663853)
