Product Information
87808-1-PBS targets PPP1R12B in WB, IF/ICC, Indirect ELISA applications and shows reactivity with human, mouse, rat samples.
| Tested Reactivity | human, mouse, rat |
| Host / Isotype | Rabbit / IgG |
| Class | Recombinant |
| Type | Antibody |
| Immunogen |
CatNo: Ag4185 Product name: Recombinant human PPP1R12B protein Source: e coli.-derived, PGEX-4T Tag: GST Domain: 1-386 aa of BC034430 Sequence: MAELEHLGGKRAESARMRRAEQLRRWRGSLTEQEPAERRGAGRQPLTRRGSPRVRFEDGAVFLAACSSGDTDEVRKLLARGADINTVNVDGLTALHQACIDENLDMVKFLVENRANVNQQDNEGWTPLHAAASCGYLNIAEYFINHGASVGIVNSEGEVPSDLAEEPAMKDLLLEQVKKQGVDLEQSRKEEEQQMLQDARQWLNSGKIEDVRQARSGATALHVAAAKGYSEVLRLLIQAGYELNVQDYDGWTPLHAAAHWGVKEACSILAEALCDMDIRNKLGQTPFDVADEGLVEHLELLQKKQNVLRSEKETRNKLIESDLNSKIQSGFFKNKEKMLYEEETPKSQEMEEENKESSSSSSEEEEGEDEASESETEKEAVLFWPF Predict reactive species |
| Full Name | protein phosphatase 1, regulatory (inhibitor) subunit 12B |
| Calculated Molecular Weight | 982 aa, 110 kDa |
| Observed Molecular Weight | 110-130 kDa |
| GenBank Accession Number | BC034430 |
| Gene Symbol | PPP1R12B |
| Gene ID (NCBI) | 4660 |
| RRID | AB_3745761 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification Method | Protein A purification |
| UNIPROT ID | O60237 |
| Storage Buffer | PBS only, pH 7.3. |
| Storage Conditions | Store at -80°C. |
Background Information
PPP1R12B (MYPT2) is a critical regulatory subunit of protein phosphatase 1, primarily functioning in muscle tissues to control myosin phosphatase activity and calcium sensitivity of contraction. Its tissue-specific expression, particularly enrichment in heart and skeletal muscle, along with multiple alternatively spliced isoforms, enables specialized roles in different cellular contexts. The protein's ankyrin repeats and C-terminal kinase-interacting domain facilitate its function as a molecular scaffold that directs PP1 catalytic activity toward specific substrates.
