PSEN2-Specific Polyclonal antibody, PBS Only

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  WB analysis using 16168-1-AP (same clone as 16168-1-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 16168-1-AP (PSEN2-Specific antibody) at dilution of 1:800 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 16168-1-PBS in a different storage buffer formulation.

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  WB analysis of A549 using 16168-1-AP (same clone as 16168-1-PBS)

  WB result of PSEN2-Specific antibody (16168-1-AP; 1:1200; incubated at room temperature for 1.5 hours) with sh-Control and sh-PSEN2-Specific transfected A549 cells. This data was developed using the same antibody clone with 16168-1-PBS in a different storage buffer formulation.

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  IHC staining of human kidney using 16168-1-AP (same clone as 16168-1-PBS)

  Immunohistochemical analysis of paraffin-embedded human kidney tissue slide using 16168-1-AP (PSEN2-Specific Antibody) at dilution of 1:200 (under 10x lens). This data was developed using the same antibody clone with 16168-1-PBS in a different storage buffer formulation.

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  IHC staining of human kidney using 16168-1-AP (same clone as 16168-1-PBS)

  Immunohistochemical analysis of paraffin-embedded human kidney tissue slide using 16168-1-AP (PSEN2-Specific Antibody) at dilution of 1:200 (under 40x lens). This data was developed using the same antibody clone with 16168-1-PBS in a different storage buffer formulation.

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  IHC staining of human placenta using 16168-1-AP (same clone as 16168-1-PBS)

  Immunohistochemical analysis of paraffin-embedded human placenta tissue slide using 16168-1-AP (PSEN2-Specific Antibody) at dilution of 1:200 (under 10x lens). This data was developed using the same antibody clone with 16168-1-PBS in a different storage buffer formulation.

• 

  IHC staining of human placenta using 16168-1-AP (same clone as 16168-1-PBS)

  Immunohistochemical analysis of paraffin-embedded human placenta tissue slide using 16168-1-AP (PSEN2-Specific Antibody) at dilution of 1:200 (under 40x lens). This data was developed using the same antibody clone with 16168-1-PBS in a different storage buffer formulation.

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  IHC staining of mouse brain using 16168-1-AP (same clone as 16168-1-PBS)

  Immunohistochemical analysis of paraffin-embedded mouse brain tissue slide using 16168-1-AP (PSEN2-Specific antibody) at dilution of 1:200 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 16168-1-PBS in a different storage buffer formulation.

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  IHC staining of human breast cancer using 16168-1-AP (same clone as 16168-1-PBS)

  Immunohistochemical analysis of paraffin-embedded human breast cancer using 16168-1-AP (PSEN2-Specific antibody) at dilution of 1:50 (under 10x lens). This data was developed using the same antibody clone with 16168-1-PBS in a different storage buffer formulation.

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  IHC staining of human breast cancer using 16168-1-AP (same clone as 16168-1-PBS)

  Immunohistochemical analysis of paraffin-embedded human breast cancer using 16168-1-AP (PSEN2-Specific antibody) at dilution of 1:50 (under 40x lens). This data was developed using the same antibody clone with 16168-1-PBS in a different storage buffer formulation.

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  IHC staining of human colon using 16168-1-AP (same clone as 16168-1-PBS)

  Immunohistochemical analysis of paraffin-embedded human colon tissue slide using 16168-1-AP (PSEN2-Specific Antibody) at dilution of 1:50 (under 10x lens). This data was developed using the same antibody clone with 16168-1-PBS in a different storage buffer formulation.

• 

  IHC staining of human colon using 16168-1-AP (same clone as 16168-1-PBS)

  Immunohistochemical analysis of paraffin-embedded human colon tissue slide using 16168-1-AP (PSEN2-Specific Antibody) at dilution of 1:50 (under 40x lens). This data was developed using the same antibody clone with 16168-1-PBS in a different storage buffer formulation.

• Featured Product
• KD/KO Validated

PSEN2-Specific Polyclonal Antibody for WB, IHC, ELISA

Cat No. 16168-1-PBS

Host / Isotype

Rabbit / IgG

Reactivity

human, mouse, rat

Applications

WB, IHC, ELISA

Synonyms

PSEN2, E5-1, EC:3.4.23.-, Presenilin 2, Presenilin-2

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Product Information

16168-1-PBS targets PSEN2-Specific in WB, IHC, ELISA applications and shows reactivity with human, mouse, rat samples.

• Tested Reactivity: human, mouse, rat
• Host / Isotype: Rabbit / IgG
• Class: Polyclonal
• Type: Antibody
• Immunogen:

  Peptide

• Full Name: presenilin 2 (Alzheimer disease 4)
• Calculated Molecular Weight: 50 kDa
• Observed Molecular Weight: 55-60 kDa
• GenBank Accession Number: NM_000447
• Gene Symbol: PSEN2
• Gene ID (NCBI): 5664
• RRID: AB_2170748
• Conjugate: Unconjugated
• Form: Liquid
• Purification Method: Antigen affinity purification
• UNIPROT ID: P49810
• Storage Buffer: PBS only, pH 7.3.
• Storage Conditions: Store at -80°C.

Background Information

Presenilins can regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. These transmembrane proteins are considered to be involved in early onset of Alzheimer's disease. Presenilin 2 mainly localizes in large neurons. It exists in a heterodimeric complex formed from the endoproteolytically processed amino-terminal (34 kDa) and carboxy-terminal (about 23 kDa) fragments.This antibody is specific to presenilin 2. It will not bind presenilin 1.