PTPRR Polyclonal antibody

PTPRR Polyclonal Antibody for WB, ELISA

Host / Isotype

Rabbit / IgG

Reactivity

human, mouse, rat

Applications

WB, IF, IHC, ELISA

Conjugate

Unconjugated

Cat no : 17937-1-AP

Synonyms

Ch 1PTPase, EC PTP, ECPTP, NC PTPCOM1, PCPTP1, PTP SL, PTPBR7, PTPRQ, PTPRR, R PTP R



Tested Applications

Positive WB detected inHeLa cells, mouse brain tissue, COLO 320 cells, SH-SY5Y cells

Recommended dilution

ApplicationDilution
Western Blot (WB)WB : 1:500-1:2000
It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, Check data in validation data gallery.

Product Information

17937-1-AP targets PTPRR in WB, IF, IHC, ELISA applications and shows reactivity with human, mouse, rat samples.

Tested Reactivity human, mouse, rat
Cited Reactivityhuman, mouse
Host / Isotype Rabbit / IgG
Class Polyclonal
Type Antibody
Immunogen PTPRR fusion protein Ag12145
Full Name protein tyrosine phosphatase, receptor type, R
Calculated Molecular Weight657 aa, 74 kDa
Observed Molecular Weight 32 kDa, 47 kDa, 65 kDa
GenBank Accession NumberBC110900
Gene Symbol PTPRR
Gene ID (NCBI) 5801
RRIDAB_10694430
Conjugate Unconjugated
Form Liquid
Purification MethodAntigen affinity purification
Storage Buffer PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Storage ConditionsStore at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. 20ul sizes contain 0.1% BSA.

Background Information

PTPRR(protein tyrosine phosphatase, receptor type, R) is also named as PCPTP1, PTP-SL, PTPBR7 and belongs to the protein-tyrosine phosphatase family. It sequesters mitogen-activated protein kinases (MAPKs) such as MAPK1, MAPK3 and MAPK14 in the cytoplasm in an inactive form. It has four isoforms that they have molecular weights of 72, 60, 42 and 37 kDa, respectively, and differ in the length of their N-terminal part which result in distinct subcellular localizations. All PTPRR isoforms are found to be short-lived proteins, with half-lives of around 3-5 hours, and are constitutively phosphorylated on one or two of the previously identified protein kinase A and MAP kinase target sites.

Protocols

Product Specific Protocols
WB protocol for PTPRR antibody 17937-1-APDownload protocol
Standard Protocols
Click here to view our Standard Protocols

Publications

SpeciesApplicationTitle
humanIHC

Mol Cancer

Multi-cohort validation of Ascore: an anoikis-based prognostic signature for predicting disease progression and immunotherapy response in bladder cancer

Authors - Tianlei Xie
mouseWB

J Affect Disord

PTPRR regulates ERK dephosphorylation in depression mice model.

Authors - Xinrong Li
humanWB

BMC Cancer

Androgen-regulation of the protein tyrosine phosphatase PTPRR activates ERK1/2 signalling in prostate cancer cells.

Authors - Jennifer Munkley
mouseWB,IF

Front Mol Neurosci

Downregulation of Protein Tyrosine Phosphatase Receptor Type R Accounts for the Progression of Hirschsprung Disease.

Authors - Jiao Tian