PTPRR Polyclonal antibody, PBS Only

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• PTPRR Polyclonal antibody, PBS Only (17937-1-PBS)

PTPRR Polyclonal Antibody for WB, ELISA

Cat No. 17937-1-PBS

Host / Isotype

Rabbit / IgG

Reactivity

human, mouse, rat

Applications

WB, ELISA

Synonyms

Ch-1PTPase, EC PTP, EC:3.1.3.48, ECPTP, NC-PTPCOM1

• 

  WB analysis using 17937-1-AP (same clone as 17937-1-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 17937-1-AP (PTPRR antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 17937-1-PBS in a different storage buffer formulation.

• 

  WB analysis of mouse brain using 17937-1-AP (same clone as 17937-1-PBS)

  mouse brain tissue were subjected to SDS PAGE followed by western blot with 17937-1-AP (PTPRR antibody) at dilution of 1:500 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 17937-1-PBS in a different storage buffer formulation.

• 

  WB analysis of COLO 320 using 17937-1-AP (same clone as 17937-1-PBS)

  COLO 320 cells were subjected to SDS PAGE followed by western blot with 17937-1-AP (PTPRR antibody) at dilution of 1:500 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 17937-1-PBS in a different storage buffer formulation.

• 

  WB analysis of HeLa using 17937-1-AP (same clone as 17937-1-PBS)

  HeLa cells were subjected to SDS PAGE followed by western blot with 17937-1-AP (PTPRR antibody) at dilution of 1:500 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 17937-1-PBS in a different storage buffer formulation.

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Product Information

17937-1-PBS targets PTPRR in WB, ELISA applications and shows reactivity with human, mouse, rat samples.

• Tested Reactivity: human, mouse, rat
• Host / Isotype: Rabbit / IgG
• Class: Polyclonal
• Type: Antibody
• Immunogen:

  CatNo: Ag12145

  Product name: Recombinant human PTPRR protein

  Source: e coli.-derived, PGEX-4T

  Tag: GST

  Domain: 1-412 aa of BC110900

  Sequence: MILYRLKERFQLSLRQDKEKNQEIHLSPITLQPALSEAKTVHSMVQPEQAPKVLNVVVDPQGRGAPEIRATTATSVCPSPFKMKPIGLQERRGSNVSLTLDMSSLGNIEPFVSIPTPREKVAMEYLQSASRILTRSQLRDVVASSHLLQSEFMEIPMNFVDPKEIDIPRHGTKNRYKTILPNPLSRVCLRPKNVTDSLSTYINANYIRGYSGKEKAFIATQGPMINTVDDFWQMVWQEDSPVIVMITKLKEKNEKCVLYWPEKRGIYGKVEVLVISVNECDNYTIRNLVLKQGSHTQHVKHYWYTSWPDHKTPDSAQPLLQLMLDVEEDRLASQGRGPVVVHCSAGIGRTGCFIATSIGCQQLKEEGVVDALSIVCQLRMDRGGMVQTSEQYEFVHHALCLYESRLSAETVQ

• Full Name: protein tyrosine phosphatase, receptor type, R
• Calculated Molecular Weight: 657 aa, 74 kDa
• Observed Molecular Weight: 32 kDa, 47 kDa, 65 kDa
• GenBank Accession Number: BC110900
• Gene Symbol: PTPRR
• Gene ID (NCBI): 5801
• RRID: AB_10694430
• Conjugate: Unconjugated
• Form: Liquid
• Purification Method: Antigen affinity purification
• UNIPROT ID: Q15256
• Storage Buffer: PBS only, pH 7.3.
• Storage Conditions: Store at -80°C.

Background Information

PTPRR(protein tyrosine phosphatase, receptor type, R) is also named as PCPTP1, PTP-SL, PTPBR7 and belongs to the protein-tyrosine phosphatase family. It sequesters mitogen-activated protein kinases (MAPKs) such as MAPK1, MAPK3 and MAPK14 in the cytoplasm in an inactive form. It has four isoforms that they have molecular weights of 72, 60, 42 and 37 kDa, respectively, and differ in the length of their N-terminal part which result in distinct subcellular localizations. All PTPRR isoforms are found to be short-lived proteins, with half-lives of around 3-5 hours, and are constitutively phosphorylated on one or two of the previously identified protein kinase A and MAP kinase target sites.