Product Information
85217-4-PBS targets Plakophilin 1 in WB, Indirect ELISA applications and shows reactivity with human, mouse samples.
Tested Reactivity | human, mouse |
Host / Isotype | Rabbit / IgG |
Class | Recombinant |
Type | Antibody |
Immunogen | Plakophilin 1 fusion protein Ag18153 Predict reactive species |
Full Name | plakophilin 1 (ectodermal dysplasia/skin fragility syndrome) |
Calculated Molecular Weight | 747 aa, 83 kDa |
Observed Molecular Weight | 70-75 kDa |
GenBank Accession Number | BC114571 |
Gene Symbol | PKP1 |
Gene ID (NCBI) | 5317 |
Conjugate | Unconjugated |
Form | Liquid |
Purification Method | Protein A purification |
UNIPROT ID | Q13835 |
Storage Buffer | PBS only, pH 7.3. |
Storage Conditions | Store at -80°C. |
Background Information
Plakophilin 1, also known as PKP1, B6P, is a member of the arm-repeat protein family. PKP1 contains arm-repeat (armadillo) domains, localizes to nuclei and cell desmosomes, and participates in linking cadherins to intermediate filaments in the cytoskeleton (PMID: 10747098). PKP1 contributes to epidermal morphogenesis and facilitates the formation of intermediate filaments. Mutations in PKP1 have been associated with the ectodermal dysplasia/skin fragility syndrome (PubMed:9326952, 10852826).