QSER1 Polyclonal antibody, PBS Only

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• QSER1 Polyclonal antibody, PBS Only (55326-1-PBS)

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  IHC staining of human pancreas cancer using 55326-1-AP (same clone as 55326-1-PBS)

  Immunohistochemical analysis of paraffin-embedded human pancreas cancer tissue slide using 55326-1-AP (QSER1 antibody) at dilution of 1:200 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 55326-1-PBS in a different storage buffer formulation.

• 

  IHC staining of human pancreas cancer using 55326-1-AP (same clone as 55326-1-PBS)

  Immunohistochemical analysis of paraffin-embedded human pancreas cancer tissue slide using 55326-1-AP (QSER1 antibody) at dilution of 1:200 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 55326-1-PBS in a different storage buffer formulation.

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  IF Staining of HeLa using 55326-1-AP (same clone as 55326-1-PBS)

  Immunofluorescent analysis of (4% PFA) fixed HeLa cells using QSER1 antibody (55326-1-AP) at dilution of 1:400 and CoraLite®488-Conjugated Goat Anti-Rabbit IgG(H+L) (SA00013-2). This data was developed using the same antibody clone with 55326-1-PBS in a different storage buffer formulation.

QSER1 Polyclonal Antibody for IHC, IF/ICC, Indirect ELISA

Cat No. 55326-1-PBS

Host / Isotype

Rabbit / IgG

Reactivity

human

Applications

IHC, IF/ICC, Indirect ELISA

Synonyms

glutamine and serine rich 1

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Product Information

55326-1-PBS targets QSER1 in IHC, IF/ICC, Indirect ELISA applications and shows reactivity with human samples.

• Tested Reactivity: human
• Host / Isotype: Rabbit / IgG
• Class: Polyclonal
• Type: Antibody
• Immunogen:

  Peptide

• Full Name: glutamine and serine rich 1
• Calculated Molecular Weight: 190 kDa
• GenBank Accession Number: NM_001076786
• Gene Symbol: QSER1
• Gene ID (NCBI): 79832
• RRID: AB_3743205
• Conjugate: Unconjugated
• Form: Liquid
• Purification Method: Antigen affinity purification
• UNIPROT ID: Q2KHR3
• Storage Buffer: PBS only, pH 7.3.
• Storage Conditions: Store at -80°C.

Background Information

QSER1, a recently characterized protein, whose activity has been tightly associated with the protection of DNA methylation sites in hESCs. QSER1 is widely up-regulated in multiple cancers, and its up-regulation correlates with poor clinic outcomes (PMID: 36371602). QSER1 depletion leads to NODAL de-repression and associates with increased RNA Polymerase II occupancy at YAP1bound enhancers, pointing to a QSER1 contribution maintaining low transcriptional activity on certain genomic regions (PMID: 33833093, 35210841).