RAP1GAP Recombinant antibody, PBS Only

RAP1GAP Uni-rAbTM Recombinant Antibody for IF/ICC, Indirect ELISA
Cat No. 86011-1-PBS
Clone No.250422B8

Host / Isotype

Rabbit / IgG

Reactivity

human

Applications

IF/ICC, Indirect ELISA

KIAA0474, RAP1 GTPase activating protein, Rap1 GTPase-activating protein 1, RAP1GA1, RAP1GAP1

Formulation:  PBS Only
PBS and Azide
PBS Only
Conjugate:  Unconjugated
Size/Concentration: 

-/ -

Freight/Packing: -

Quantity

Please visit your regions distributor:


Product Information

86011-1-PBS targets RAP1GAP in IF/ICC, Indirect ELISA applications and shows reactivity with human samples.

Tested Reactivity human
Host / Isotype Rabbit / IgG
Class Recombinant
Type Antibody
Immunogen RAP1GAP fusion protein Ag5576 Predict reactive species
Full Name RAP1 GTPase activating protein
Calculated Molecular Weight 73 kDa
GenBank Accession NumberBC054490
Gene Symbol RAP1GAP
Gene ID (NCBI) 5909
Conjugate Unconjugated
Form Liquid
Purification MethodProtein A purification
UNIPROT IDP47736
Storage Buffer PBS only, pH 7.3.
Storage ConditionsStore at -80°C.

Background Information

Rap1 GTPase-activating protein (Rap1GAP) is an important tumor suppressor. Rap1GAP was associated with the AMPK and NF-κB signaling pathways and that Rap1GAP inhibited AMPK/SIRT1 and activated the NF-κB signaling pathway in model animals. Rap1GAP was verified to regulate the AMPK SIRT1/NF-κB signaling pathway and exacerbate the damage to myocardial cells caused by ischemia and hypoxia (PMID: 38320624). Rap1GAP is involved in Ang II-induced cardiomyocyte hypertrophy through the regulation of autophagy (PMID: 33936386). Rap1GAP, which is the GTPase-activating protein of Rap1, can bind to Rap1, promote the transformation of GTP from its active to inactive form, and terminate signal transduction (PMID: 21295042).

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