RASGRF1 Monoclonal antibody
RASGRF1 Monoclonal Antibody for WB, ELISA
Host / Isotype
Mouse / IgG1
Cat no : 67010-1-Ig
|Positive WB detected in
|pig cerebellum tissue, pig brain tissue, rat brain tissue, rat cerebellum tissue
|Western Blot (WB)
|WB : 1:1000-1:6000
|It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
|Sample-dependent, check data in validation data gallery
67010-1-Ig targets RASGRF1 in WB, ELISA applications and shows reactivity with rat, pig samples.
|Host / Isotype
|Mouse / IgG1
|RASGRF1 fusion protein Ag6937
|Ras protein-specific guanine nucleotide-releasing factor 1
|Calculated molecular weight
|Observed molecular weight
|GenBank accession number
|Gene ID (NCBI)
|Protein A purification
|PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
|Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. 20ul sizes contain 0.1% BSA.
RasGRF1, a member of calmodulin-activated guanine-nucleotide exchange factors (GEFs), highly expressed at the synaptic junctions of the central nervous system (CNS). It is similar to the Saccharomyces cerevisiae CDC25. RASGRF1 serves as an in vivo activator for H-RAS and members of the R-RAS and RAC subfamilies. Several studies have shown that RasGRF1 also binds to microtubules and participate in the regulation of neurite outgrowth. RasGRF1 has been implicated in neuronal excitability. The studies of the similar gene in mouse suggested that the Ras-GEF activity of this protein in brain can be activated by Ca2+ influx, muscarinic receptors, and G protein beta-gamma subunit. Mouse studies also indicated that the Ras-GEF signaling pathway mediated by this protein may be important for long-term memory.