Product Information
31232-1-PBS targets RTTN in WB, Indirect ELISA applications and shows reactivity with human samples.
| Tested Reactivity | human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen |
CatNo: Ag34960 Product name: Recombinant human RTTN protein Source: e coli.-derived, PGEX-4T Tag: GST Domain: 1417-1530 aa of NM_173630 Sequence: TVVNILLDQSECSMVRREAAFILQNLLVIPMPTEIIKDYTWQGPCVHDEDSGLSLIGKPALQALLYHCHFYEHLNQMVKHCYLGRCMFDLNFSAFDRNSESNDLNGLDDSFKFW Predict reactive species |
| Full Name | rotatin |
| Calculated Molecular Weight | 249 kDa |
| Observed Molecular Weight | 246 kDa |
| GenBank Accession Number | NM_173630 |
| Gene Symbol | RTTN |
| Gene ID (NCBI) | 25914 |
| RRID | AB_3742412 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification Method | Antigen affinity Purification |
| UNIPROT ID | Q86VV8 |
| Storage Buffer | PBS only, pH 7.3. |
| Storage Conditions | Store at -80°C. |
Background Information
RTTN, also known as Rotatin, is an evolutionarily conserved protein that is associated with the centrosome and plays a crucial role in centriole biogenesis. It is found in many organisms and was initially identified in a mutant mouse that exhibited defects in axial rotation and left-right specification. RTTN is required for proper mitotic progression, the maintenance of spindle pole integrity, and correct spindle positioning. Loss of RTTN can lead to mitotic defects, including G2/M phase arrest and increased aneuploidy cells.
