Recombinant Rat ACVR1 protein (rFc Tag)
Species
Rat
Purity
>90 %, SDS-PAGE
Tag
rFc Tag
Activity
not tested
Cat no : Eg3420
Validation Data Gallery
Product Information
| Purity | >90 %, SDS-PAGE |
| Endotoxin | <0.1 EU/μg protein, LAL method |
| Activity |
Not tested |
| Expression | HEK293-derived Rat ACVR1 protein Met21-Glu123 (Accession# P80201) with a rabbit IgG Fc tag at the C-terminus. |
| GeneID | 79558 |
| Accession | P80201 |
| PredictedSize | 37.8 kDa |
| SDS-PAGE | 39-49 kDa, reducing (R) conditions |
| Formulation | Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization. |
| Reconstitution | Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water. |
| Storage Conditions |
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
|
| Shipping | The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature. |
Background
Activin A receptor type I (ACVR1) is a transmembrane serine/threonine kinase and belongs to the transforming growth factor-β superfamily. It is involved in a wide variety of biological processes, including bone, heart, cartilage, nervous, and reproductive system development and regulation. ACVR1 plays an important role in hematopoiesis and anemia via the BMP6/ACVR1/SMADpathway, which regulates expression of hepcidin, the master regulator of iron homeostasis.
References:
1.Valer JA. et al. (2019) Cells. 8(11):1366. 2.Nagar G. et al. (2023) Brief Funct Genomics. 22(2):123-142. 3.Duminuco A. et al. (2023) Cancers (Basel). 16(1):154.