Recombinant Rat DDR1 protein (rFc Tag)

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• Recombinant Rat DDR1 protein (rFc Tag) (Eg3226)

Species

Rat

Purity

>90 %, SDS-PAGE

Tag

rFc Tag

Activity

not tested

Cat no : Eg3226

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Validation Data Gallery

• 

  Purity of Recombinant Rat DDR1 was determined by SDS-PAGE. The protein was resolved in an SDS-PAGE in reducing (R) and non-reducing (NR) conditions and stained using Coomassie blue.

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Product Information

• Purity: >90 %, SDS-PAGE
• Endotoxin: <0.1 EU/μg protein, LAL method
• Activity:

  Not tested

• Expression: HEK293-derived Rat DDR1 protein Asp22-Thr413 (Accession# A6KT95) with a rabbit IgG Fc tag at the C-terminus.
• GeneID: 25678
• Accession: A6KT95
• PredictedSize: 69.9 kDa
• SDS-PAGE: 70-85 kDa, reducing (R) conditions
• Formulation: Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization.
• Reconstitution: Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water.
• Storage Conditions:
  It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
  • Until expiry date, -20℃ to -80℃ as lyophilized proteins.
  • 3 months, -20℃ to -80℃ under sterile conditions after reconstitution.
• Shipping: The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature.

Background

Discoidin Domain Receptor 1 (DDR1) is a receptor tyrosine kinase that is activated by fibrillar collagens, playing a pivotal role in cellular functions such as proliferation, differentiation, invasion, migration, survival, matrix remodeling, and cytokine expression. DDR1 is predominantly found in epithelial and smooth muscle cells, and its expression is mainly limited to epithelial cells located in several organs, including skin, kidney, liver, and lung. DDR1 has been implicated in a wide range of human diseases, including various types of cancer, fibrosis (such as liver/kidney/pulmonary fibrosis), inflammation, and atherosclerosis. High expression or mutation of DDR1 is associated with many cancers.

References:

1. Liu M. et al. (2024). Eur J Med Chem. 268:116291.
2. Moll S. et al. (2019). Biochim Biophys Acta Mol Cell Res. 1866(11):118474.
3. Hou G. et al. (2002). Circ Res. 90(11):1147-1149.