Recombinant Rat NXPH1 protein (mFc Tag)
Species
Rat
Purity
>90 %, SDS-PAGE
Tag
mFc Tag
Activity
not tested
Cat no : Eg3227
Validation Data Gallery
Product Information
| Purity | >90 %, SDS-PAGE |
| Endotoxin | <0.1 EU/μg protein, LAL method |
| Activity |
Not tested |
| Expression | HEK293-derived Rat NXPH1 protein Ala22-Gly271 (Accession# Q63366) with a mouse IgG Fc tag at the C-terminus. |
| GeneID | 25501 |
| Accession | Q63366 |
| PredictedSize | 55.2 kDa |
| SDS-PAGE | 68-85 kDa, reducing (R) conditions |
| Formulation | Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization. |
| Reconstitution | Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water. |
| Storage Conditions |
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
|
| Shipping | The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature. |
Background
Neurexophilin-1 (NXPH1) is a secretory protein that belongs to the Neurexophilin family. NXPH1 is known to code for a neuronal glycoprotein that binds to α-neurexin to regulate neuronal function, neurotransmission, signalization and various cell interactions. NXPH1 expression is enriched in adrenal gland and brain. NXPH1 has also been identified as a novel biomarker for the prognosis of neuroblastoma, and for the diagnosis of low-grade breast cancer.
References:
1.Vallée Marcotte B. et al. (2017) Int J Mol Sci. 18(2):257. 2. Fanlo L. et al. (2023) Oncogene. 42(28):2218-2233. 3. Sun Z. et al. (2024) J Gastrointest Oncol. 15(2):641-667.