RyDEN Recombinant monoclonal antibody, PBS Only

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• RyDEN Recombinant monoclonal antibody, PBS Only (88428-1-PBS)

RyDEN Uni-rAb^® Recombinant Antibody for WB, Indirect ELISA

Cat No. 88428-1-PBS

Clone No.260958E12

Host / Isotype

Rabbit / IgG

Reactivity

human, mouse, rat

Applications

WB, Indirect ELISA

Synonyms

C19orf66, Interferon-regulated antiviral protein, IRAV, Repressor of yield of DENV protein, SFL

• 

  WB analysis using 88428-1-RR (same clone as 88428-1-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 88428-1-RR (RyDEN antibody) at dilution of 1:10000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 88428-1-PBS in a different storage buffer formulation.

  This validation data has been generated in-house and reviewed by Proteintech scientists. Find out more on our antibody validation policy

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Product Information

88428-1-PBS targets RyDEN in WB, Indirect ELISA applications and shows reactivity with human, mouse, rat samples.

• Tested Reactivity: human, mouse, rat
• Host / Isotype: Rabbit / IgG
• Class: Recombinant
• Type: Antibody
• Immunogen:

  CatNo: Ag42748

  Product name: Recombinant human C19orf66 protein

  Source: e coli.-derived, PET30a

  Tag: 6*His

  Domain: 1-255 aa of BC035817

  Sequence: MSQEGVELEKSVRRLREKFHGKVSSKKAGALMRKFGSDHTGVGRSIVYGVKQKDGQELSNDLDAQDPPEDMKQDRDIQAVATSLLPLTEANLRMFQRAQDDLIPAVDRQFACSSCDHVWWRRVPQRKEVSRCRKCRKRYEPVPADKMWGLAEFHCPKCRHNFRTHTHSCSAADCYNRREPHVPGTSCAHPKSRKQNHLPKVLHPSNPHISSGSTVATCLSQGGLLEDLDNLILEDLKEEEEEEEEVEDEEGGPRE

• Full Name: chromosome 19 open reading frame 66
• Observed Molecular Weight: 38 kDa
• GenBank Accession Number: BC035817
• Gene Symbol: C19orf66
• Gene ID (NCBI): 55337
• Conjugate: Unconjugated
• Form: Liquid
• Purification Method: Protein A purification
• UNIPROT ID: Q9NUL5
• Storage Buffer: PBS only, pH 7.3.
• Storage Conditions: Store at -80°C.

Background Information

The shiftless antiviral inhibitor of ribosomal frameshifting (SHFL) gene was firstly predicted as an ISG in 2011, which is also named as C19orf66, FLJ11286, IRAV, UPF0515, and RyDEN. SHFL showed high expressing level in human liver and spleen tissues, whereas a lower expression is observed in the pancreas and heart. SHFL is a novel ISG that inhibits dengue virus (DENV), West Nile virus (WNV), Zika virus (ZIKV), and Japanese encephalitis virus (JEV) infections. Interestingly, SHFL functions as a broad-spectrum antiviral factor exhibiting suppressive activity against various types of RNA and DNA viruses. (PMID: 36293480, PMID: 26735137, PMID: 38149274)