SCN11A Recombinant antibody, PBS Only

• 

  WB analysis using 85740-1-RR (same clone as 85740-1-PBS)

  rat brain tissue were subjected to SDS PAGE followed by western blot with 85740-1-RR (SCN11A antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 85740-1-PBS in a different storage buffer formulation.

SCN11A Uni-rAb^TM Recombinant Antibody for WB, Indirect ELISA

Cat No. 85740-1-PBS

Clone No.250003E1

Host / Isotype

Rabbit / IgG

Reactivity

human, rat

Applications

WB, Indirect ELISA

Synonyms

hNaN, NaN, NAV1.9, PN5, SCN12A

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Product Information

85740-1-PBS targets SCN11A in WB, Indirect ELISA applications and shows reactivity with human, rat samples.

• Tested Reactivity: human, rat
• Host / Isotype: Rabbit / IgG
• Class: Recombinant
• Type: Antibody
• Immunogen: Peptide
• Full Name: sodium channel, voltage-gated, type XI, alpha subunit
• Calculated Molecular Weight: 205 kDa
• Observed Molecular Weight: 205 kDa
• GenBank Accession Number: NM_001349253
• Gene Symbol: SCN11A
• Gene ID (NCBI): 11280
• Conjugate: Unconjugated
• Form: Liquid
• Purification Method: Protein A purification
• UNIPROT ID: Q9UI33
• Storage Buffer: PBS only, pH 7.3.
• Storage Conditions: Store at -80°C.

Background Information

Sodium channel protein type 11 subunit alpha (SCN11A, also known as Nav1.9) is crucial for generating action potentials and regulating neuronal excitability, particularly in nociceptive neurons of the dorsal root ganglia (DRG) and trigeminal ganglia (PMID: 33752606). Nav1.9 channels are involved in the formation of pain-sensing and have been implicated in peripheral inflammatory pain hypersensitivity. Additionally, SCN11A-mediated channels play a role in regulating colonic motility and neurotransmitter release in the enteric nervous system (PMID: 35711274).