SDCCAG1 Polyclonal antibody, PBS Only

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• SDCCAG1 Polyclonal antibody, PBS Only (11840-1-PBS)

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  WB analysis using 11840-1-AP (same clone as 11840-1-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 11840-1-AP (SDCCAG1 antibody) at dilution of 1:3000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 11840-1-PBS in a different storage buffer formulation.

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  IP experiment of A549 using 11840-1-AP (same clone as 11840-1-PBS)

  IP result of anti-SDCCAG1 (IP:11840-1-AP, 4ug; Detection:11840-1-AP 1:500) with A549 cells lysate 1800ug. This data was developed using the same antibody clone with 11840-1-PBS in a different storage buffer formulation.

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  IHC staining of human lung cancer using 11840-1-AP (same clone as 11840-1-PBS)

  Immunohistochemical analysis of paraffin-embedded human lung cancer tissue slide using 11840-1-AP (SDCCAG1 antibody) at dilution of 1:500 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 11840-1-PBS in a different storage buffer formulation.

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  IHC staining of human lung cancer using 11840-1-AP (same clone as 11840-1-PBS)

  Immunohistochemical analysis of paraffin-embedded human lung cancer tissue slide using 11840-1-AP (SDCCAG1 antibody) at dilution of 1:500 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 11840-1-PBS in a different storage buffer formulation.

• Featured Product
• KD/KO Validated

SDCCAG1 Polyclonal Antibody for WB, IHC, IP, Indirect ELISA

Cat No. 11840-1-PBS

Host / Isotype

Rabbit / IgG

Reactivity

human, mouse, rat

Applications

WB, IHC, IP, Indirect ELISA

Synonyms

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Product Information

11840-1-PBS targets SDCCAG1 in WB, IHC, IP, Indirect ELISA applications and shows reactivity with human, mouse, rat samples.

• Tested Reactivity: human, mouse, rat
• Host / Isotype: Rabbit / IgG
• Class: Polyclonal
• Type: Antibody
• Immunogen:

  CatNo: Ag2467

  Product name: Recombinant human SDCCAG1 protein

  Source: e coli.-derived, PGEX-4T

  Tag: GST

  Domain: 48-397 aa of BC020794

  Sequence: EDITLQSGRDELNEELIQEESSEDEGEYEEVRKDQDSVGEMKDEGEETLNYPDTTIDLSHLQPQRSIQKLASKEESSNSSDSKSQSRRHLSAKERREMKKKKLPSDSGDLEALEGKDKEKESTVHIETHQNTSKNVAAVQPMKRGQKSKMKKMKEKYKDQDEEDRELIMKLLGSAGSNKEEKGKKGKKGKTKDEPVKKQPQKPRGGQRVSDNIKKETPFLEVITHELQDFAVDDPHDDKEEQDLDQQGNEENLFDSLTGQPHPEDVLLFAIPICAPYTTMTNYKYKVKLTPGVQKKGKAAKTALNSFMHSKEATAREKDLFRSVKDTDLSRNIPGKVKVSAPNLLNVKRK

• Full Name: serologically defined colon cancer antigen 1
• Calculated Molecular Weight: 1076 aa, 123 kDa
• Observed Molecular Weight: 130-140 kDa
• GenBank Accession Number: BC020794
• Gene Symbol: SDCCAG1
• Gene ID (NCBI): 9147
• RRID: AB_2183413
• Conjugate: Unconjugated
• Form: Liquid
• Purification Method: Antigen affinity purification
• UNIPROT ID: O60524
• Storage Buffer: PBS only, pH 7.3.
• Storage Conditions: Store at -80°C.

Background Information

SDCCAG1, also named as NEMF, is a nuclear export mediator. It can be bound to translocon-engaged 60S subunits on native ER membranes. Human SDCCAG1 has been implicated in lung cancers and it may function as a tumor suppressor gene. SDCCAG1 inactivation contributes to the transformed state of human lung cancer cells (PMID:16103875, 10575219). NEMF is also regarded as a potential biomarker for the detection of active and latent TB infections (PMID: 26818387).