SIGLEC10 Monoclonal antibody, PBS Only

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• SIGLEC10 Monoclonal antibody, PBS Only (60547-1-PBS)

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  WB analysis of TF-1 using 60547-1-Ig (same clone as 60547-1-PBS)

  TF-1 cells were subjected to SDS PAGE followed by western blot with 60547-1-Ig (SIGLEC10 antibody) at dilution of 1:5000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 60547-1-PBS in a different storage buffer formulation.

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  WB analysis of Karpas-422 using 60547-1-Ig (same clone as 60547-1-PBS)

  Karpas-422 cells were subjected to SDS PAGE followed by western blot with 60547-1-Ig (SIGLEC10 antibody) at dilution of 1:5000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 60547-1-PBS in a different storage buffer formulation.

SIGLEC10 Monoclonal Antibody for WB, Indirect ELISA

Cat No. 60547-1-PBS

Clone No.2E9D7

Host / Isotype

Mouse / IgG2a

Reactivity

human

Applications

WB, Indirect ELISA

Synonyms

Siglec-10, 2E9D7, Sialic acid-binding Ig-like lectin 10, SIGLEC 10, Siglec like protein 2

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Product Information

60547-1-PBS targets SIGLEC10 in WB, Indirect ELISA applications and shows reactivity with human samples.

• Tested Reactivity: human
• Host / Isotype: Mouse / IgG2a
• Class: Monoclonal
• Type: Antibody
• Immunogen:

  CatNo: Ag20755

  Product name: Recombinant human SIGLEC10 protein

  Source: e coli.-derived, PET28a

  Tag: 6*His

  Domain: 39-400 aa of BC101725

  Sequence: VPCSFSYPRQDWTGSTPAYGYWFKAVTETTKGAPVATNHQSREVEMSTRGRFQLTGDPAKGNCSLVIRDAQMQDESQYFFRVERGSYVRYNFMNDGFFLKVTALTQKPDVYIPETLEPGQPVTVICVFNWAFEECPPPSFSWTGAALSSQGTKPTTSHFSVLSFTPRPQDHNTDLTCHVDFSRKGVSVQRTVRLRVAYAPRDLVISISRDNTPALEPQPQGNVPYLEAQKGQFLRLLCAADSQPPATLSWVLQNRVLSSSHPWGPRPLGLELPGVKAGDSGRYTCRAENRLGSQQRALDLSVQYPPENLRVMVSQANRTVLENLGNGTSLPVLEGQSLCLVCVTHSSPPARLSWTQRGQVLS

• Full Name: sialic acid binding Ig-like lectin 10
• Calculated Molecular Weight: 697 aa, 77 kDa
• Observed Molecular Weight: 70-100 kDa
• GenBank Accession Number: BC101725
• Gene Symbol: SIGLEC10
• Gene ID (NCBI): 89790
• RRID: AB_3743220
• Conjugate: Unconjugated
• Form: Liquid
• Purification Method: Protein A purification
• UNIPROT ID: Q96LC7
• Storage Buffer: PBS only, pH 7.3.
• Storage Conditions: Store at -80°C.

Background Information

Sialic acid-binding Ig-like lectin 10 (SIGLEC10) is a single-pass type I membrane protein selectively expressed in the immune system, with high abundance in peripheral blood leukocytes (PMID: 11733002). Siglec-10 interacts with CD24 on innate immune cells to attenuate inflammatory responses in multiple diseases. The CD24/Siglec-10 signaling pathway is involved in cancer immunotherapy via macrophages (PMID: 38279998; 31367043).