SLA2 Polyclonal antibody, PBS Only

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• SLA2 Polyclonal antibody, PBS Only (14152-1-PBS)

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  WB analysis using 14152-1-AP (same clone as 14152-1-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 14152-1-AP (SLA2 antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 14152-1-PBS in a different storage buffer formulation.

SLA2 Polyclonal Antibody for WB, Indirect ELISA

Cat No. 14152-1-PBS

Host / Isotype

Rabbit / IgG

Reactivity

human

Applications

WB, Indirect ELISA

Synonyms

Src like adapter 2, SLAP-2, SLAP2, SLAP 2, MARS

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Product Information

14152-1-PBS targets SLA2 in WB, Indirect ELISA applications and shows reactivity with human samples.

• Tested Reactivity: human
• Host / Isotype: Rabbit / IgG
• Class: Polyclonal
• Type: Antibody
• Immunogen:

  CatNo: Ag5334

  Product name: Recombinant human SLA2 protein

  Source: e coli.-derived, PGEX-4T

  Tag: GST

  Domain: 1-261 aa of BC042041

  Sequence: MGSLPSRRKSLPSPSLSSSVQGQGPVTMEAERSKATAVALGSFPAGGPAELSLRLGEPLTIVSEDGDWWTVLSEVSGREYNIPSVHVAKVSHGWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGSYSLSVRLSRPASWDRIRHYRIHCLDNGWLYISPRLTFPSLQALVDHYSELADDICCLLKEPCVLQRAGPLPGKDIPLPVTVQRTPLNWKELDSSLLFSEAATGEESLLSEGLRESLSFYISLNDEAVSLDDA

• Full Name: Src-like-adaptor 2
• Calculated Molecular Weight: 261 aa, 29 kDa
• Observed Molecular Weight: 28-30 kDa
• GenBank Accession Number: BC042041
• Gene Symbol: SLA2
• Gene ID (NCBI): 84174
• RRID: AB_3669179
• Conjugate: Unconjugated
• Form: Liquid
• Purification Method: Antigen affinity purification
• UNIPROT ID: Q9H6Q3
• Storage Buffer: PBS only, pH 7.3.
• Storage Conditions: Store at -80°C.

Background Information

SLA2 is an adapter protein, which negatively regulates T-cell receptor (TCR) signaling. It Inhibits T-cell antigen-receptor-induced activation of nuclear factor of activated T-cells and may act by linking signaling proteins such as ZAP70 with CBL, leading to a CBL-dependent degradation of signaling proteins (PMID: 11696592).