Product Information
12242-1-AP targets SLC12A8 in WB, ELISA applications and shows reactivity with human, mouse samples.
| Tested Reactivity | human, mouse |
| Cited Reactivity | human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen |
CatNo: Ag2886 Product name: Recombinant human SLC12A8 protein Source: e coli.-derived, PGEX-4T Tag: GST Domain: 409-714 aa of BC020506 Sequence: SCSLTPVPEPVLREGAEGLHCSEHLLLEKAPSYGSEGPAQRVLEGTLLEFTKDMDQLLQLTRKLESSQPRQGEGNRTPESQKRKSKKATKQTLQDSFLLDLKSPPSFPVEISDRLPAASWEGQESCWNKQTSKSEGTQPEGTYGEQLVPELCNQSESSGEDFFLKSRLQEQDVWRRSTSFYTHMCNPWVSLLGAVGSLLIMFVIQWVYTLVNMGVAAIVYFYIGRASPGLHLGSASNFSFFRWMRSLLLPSCRSLQSPQEQIILAPSLAKVDMEMTQLTQENADFATRDRYHHSSLVNREQLMPHY Predict reactive species |
| Full Name | solute carrier family 12 (potassium/chloride transporters), member 8 |
| Calculated Molecular Weight | 714 aa, 80 kDa |
| Observed Molecular Weight | 70 KDa |
| GenBank Accession Number | BC020506 |
| Gene Symbol | SLC12A8 |
| Gene ID (NCBI) | 84561 |
| RRID | AB_3669135 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification Method | Antigen affinity purification |
| UNIPROT ID | A0AV02 |
| Storage Buffer | PBS with 0.02% sodium azide and 50% glycerol, pH 7.3. |
| Storage Conditions | Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. 20ul sizes contain 0.1% BSA. |
Background Information
Solute carrier family 12 member 8 (SLC12A8) belongs to the SLC12 gene family, which consists of electroneutral cation-chloride coupled cotransporters. It is highly expressed in small intestine and pancreas and moderately expressed in liver and white adipose tissue (PMID: 31131364). SLC12A8 may be a useful biomarker for the early diagnosis and treatment of bladder cancer (PMID: 33364434).
Publications
What published studies show
The SLC12A8 Polyclonal antibody (Cat# 12242-1-AP) has 4 citations spanning Nature Communications (×2), Functional & Integrative Genomics, and Advanced Science. Research fields include pancreatic cancer immunotherapy resistance, intestinal epithelial–T cell immune tolerance, endometriosis-associated ovarian cancer biomarker discovery, and bone marrow macrophage STING signaling in skeletal aging. Note: this product has been replaced by Cat# 31051-1-AP.
| Species | Application | Title |
|---|---|---|
Nat Commun Targeting spermine metabolism to overcome immunotherapy resistance in pancreatic cancer | ||
Nat Commun Butyrate epigenetically licenses sustained epithelial-T cell crosstalk for intestinal immune tolerance. | ||
Adv Sci (Weinh) Bone Marrow Macrophage STING Signaling is a Direct Nexus Linking Marrow Adipose Expansion to NAD(+) Depletion and Osteogenic Decline in Skeletal Aging. | ||
Funct Integr Genomics Integrative analysis and experiment validation of SLC12A8 as a biomarker for the malignant transition from endometriosis to endometriosis associated ovarian cancer.
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