Tested Applications
| Positive WB detected in | mouse kidney tissue, L02 cells, mouse heart tissue |
Recommended dilution
| Application | Dilution |
|---|---|
| Western Blot (WB) | WB : 1:500-1:3000 |
| It is recommended that this reagent should be titrated in each testing system to obtain optimal results. | |
| Sample-dependent, Check data in validation data gallery. | |
Product Information
20676-1-AP targets SLC16A2 in WB, ELISA applications and shows reactivity with human, mouse, rat samples.
| Tested Reactivity | human, mouse, rat |
| Cited Reactivity | human, mouse, rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen |
Peptide Predict reactive species |
| Full Name | solute carrier family 16, member 2 (monocarboxylic acid transporter 8) |
| Calculated Molecular Weight | 60 kDa |
| Observed Molecular Weight | 50-65 kDa |
| GenBank Accession Number | NM_006517 |
| Gene Symbol | SLC16A2 |
| Gene ID (NCBI) | 6567 |
| RRID | AB_10695188 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification Method | Antigen affinity purification |
| UNIPROT ID | P36021 |
| Storage Buffer | PBS with 0.02% sodium azide and 50% glycerol, pH 7.3. |
| Storage Conditions | Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. 20ul sizes contain 0.1% BSA. |
Background Information
SLC16A2, also named as MCT8 and XPCT, belongs to the major facilitator superfamily and Monocarboxylate porter (TC 2.A.1.13) family. SLC16A2 is a very active and specific thyroid hormone transporter. SLC16A2 stimulates cellular uptake of thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine. It does not transport Leu, Phe, Trp or Tyr. Defects in SLC16A2 are the cause of monocarboxylate transporter 8 deficiency (MCT8 deficiency). This antibody is specific to SLC16A2.
Protocols
| Product Specific Protocols | |
|---|---|
| WB protocol for SLC16A2 antibody 20676-1-AP | Download protocol |
| Standard Protocols | |
|---|---|
| Click here to view our Standard Protocols |
Publications
What published studies show
The SLC16A2 Polyclonal antibody (Cat# 20676-1-AP) has 8 total citations. These appear in journals including Int J Mol Sci, Front Pharmacol, Toxicology, iScience, Pharm Res, Microbiol Spectr, and PLoS One. Research fields span thyroid hormone homeostasis and neurotoxicity, pancreatic and glioma cancer, drug transport across the blood-brain barrier, monocarboxylate transporter expression, muscle cell remodeling, and respiratory virus-host protein interactions.
| Species | Application | Title |
|---|---|---|
Int J Mol Sci Smoothelin-Like Protein 1 Regulates the Thyroid Hormone-Induced Homeostasis and Remodeling of C2C12 Cells via the Modulation of Myosin Phosphatase. | ||
Front Pharmacol Hydrogen Sulfide Promotes Thyroid Hormone Synthesis and Secretion by Upregulating Sirtuin-1. | ||
Toxicology MiR-24-3p/Dio3 axis is essential for BDE47 to induce local thyroid hormone disorder and neurotoxicity | ||
Toxicology BDE209-promoted Dio2 degradation in H4 glioma cells through the autophagy pathway, resulting in hypothyroidism and leading to neurotoxicity | ||
iScience Microenvironmental acidosis drives PARP- and ATM inhibitor resistance in p53 deficient pancreatic cancer. | ||
Pharm Res Participation of Monocarboxylate Transporter 8, But Not P-Glycoprotein, in Carrier-Mediated Cerebral Elimination of Phenytoin across the Blood-Brain Barrier. |
Reviews
What customers say
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The reviews below have been submitted by verified Proteintech customers who received an incentive for providing their feedback.
Kristen (Verified Customer) (03-30-2026) | Worked well for WB in A375 cells- band at predicted size ~50kDA
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Casey (Verified Customer) (12-02-2025) | Blot looked really good. Band was clear.
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Jelan (Verified Customer) (11-25-2025) | The MCT8 antibody from Proteintech is great and showing specific bands that accurately reflect MCT8 expression, especially in tissues or cell lines with strong transporter activity. We in the lab appreciate its low background and reliable performance in Western blot and immunostaining applications.
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Haley (Verified Customer) (11-25-2025) | Reliable antibody
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Diana (Verified Customer) (10-17-2025) |
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