SLC22A16 Polyclonal antibody, PBS Only

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• SLC22A16 Polyclonal antibody, PBS Only (26833-1-PBS)

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  WB analysis using 26833-1-AP (same clone as 26833-1-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 26833-1-AP (SLC22A16 antibody) at dilution of 1:2000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 26833-1-PBS in a different storage buffer formulation.

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  IHC staining of human breast cancer using 26833-1-AP (same clone as 26833-1-PBS)

  Immunohistochemical analysis of paraffin-embedded human breast cancer tissue slide using 26833-1-AP (SLC22A16 antibody) at dilution of 1:200 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 26833-1-PBS in a different storage buffer formulation.

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  IHC staining of human stomach cancer using 26833-1-AP (same clone as 26833-1-PBS)

  Immunohistochemical analysis of paraffin-embedded human stomach cancer tissue slide using 26833-1-AP (SLC22A16 antibody) at dilution of 1:200 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 26833-1-PBS in a different storage buffer formulation.

• 

  IHC staining of human stomach cancer using 26833-1-AP (same clone as 26833-1-PBS)

  Immunohistochemical analysis of paraffin-embedded human stomach cancer tissue slide using 26833-1-AP (SLC22A16 antibody) at dilution of 1:200 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 26833-1-PBS in a different storage buffer formulation.

• 

  IHC staining of human breast cancer using 26833-1-AP (same clone as 26833-1-PBS)

  Immunohistochemical analysis of paraffin-embedded human breast cancer tissue slide using 26833-1-AP (SLC22A16 antibody) at dilution of 1:200 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 26833-1-PBS in a different storage buffer formulation.

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  IF Staining of THP-1 using 26833-1-AP (same clone as 26833-1-PBS)

  Immunofluorescent analysis of (4% PFA) fixed THP-1 cells using SLC22A16 antibody (26833-1-AP) at dilution of 1:200 and CoraLite®488-Conjugated AffiniPure Goat Anti-Rabbit IgG(H+L). This data was developed using the same antibody clone with 26833-1-PBS in a different storage buffer formulation.

SLC22A16 Polyclonal Antibody for WB, IHC, IF/ICC, Indirect ELISA

Cat No. 26833-1-PBS

Host / Isotype

Rabbit / IgG

Reactivity

human

Applications

WB, IHC, IF/ICC, Indirect ELISA

Synonyms

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Product Information

26833-1-PBS targets SLC22A16 in WB, IHC, IF/ICC, Indirect ELISA applications and shows reactivity with human samples.

• Tested Reactivity: human
• Host / Isotype: Rabbit / IgG
• Class: Polyclonal
• Type: Antibody
• Immunogen:

  CatNo: Ag25270

  Product name: Recombinant human SLC22A16 protein

  Source: e coli.-derived, PGEX-4T

  Tag: GST

  Domain: 48-150 aa of BC047565

  Sequence: PHHVCRPPGNVSQVVFHNHSNWSLEDTGALLSSGQKDYVTVQLQNGEIWELSRCSRNKRENTSSLGYEYTGSKKEFPCVDGYIYDQNTWKSTAVTQWNLVCDR

• Full Name: solute carrier family 22 (organic cation/carnitine transporter), member 16
• Calculated Molecular Weight: 65 kDa
• Observed Molecular Weight: 68 kDa
• GenBank Accession Number: BC047565
• Gene Symbol: SLC22A16
• Gene ID (NCBI): 85413
• RRID: AB_2923576
• Conjugate: Unconjugated
• Form: Liquid
• Purification Method: Antigen affinity purification
• UNIPROT ID: Q86VW1
• Storage Buffer: PBS only, pH 7.3.
• Storage Conditions: Store at -80°C.

Background Information

SLC22A16, also named as CT2, FLIPT2, or OCT6, belongs to the major facilitator (TC 2.A.1) superfamily and organic cation transporter (TC 2.A.1.19) family. SLC22A16 encodes an organic zwitterion transporter protein that transports carnitine and some anticancer drugs, including anthracyclines. As a carnitine transporter, SLC22A16 is involved in the regulation of fatty acid oxidation (FAO), which plays an important role also in the metabolic transformation of cancer cells. SLC22A16 expression in cancer cells is associated with increased sensitivity to the cytotoxic effects of doxorubicin. SLC22A16 has 3 isoforms with the molecular mass of 58, 61 and 65 kDa (PMID: 35761855, 35608746).