|Positive WB detected in||HeLa cells, mouse brain tissue|
|Positive IHC detected in||mouse brain tissue, human heart tissue|
Note: suggested antigen retrieval with TE buffer pH 9.0; (*) Alternatively, antigen retrieval may be performed with citrate buffer pH 6.0
|Western Blot (WB)||WB : 1:500-1:2000|
|Immunohistochemistry (IHC)||IHC : 1:50-1:500|
|Sample-dependent, check data in validation data gallery|
18992-1-AP targets SLC24A4 in WB, IHC, ELISA applications and shows reactivity with human, mouse samples.
|Tested Reactivity||human, mouse|
|Cited Reactivity||mouse, rat|
|Host / Isotype||Rabbit / IgG|
|Full Name||solute carrier family 24 (sodium/potassium/calcium exchanger), member 4|
|Calculated molecular weight||69 kDa|
|Observed molecular weight||62-90 kDa|
|GenBank accession number||NM_153646|
|Gene ID (NCBI)||123041|
|Purification Method||Antigen affinity purification|
|Storage Buffer||PBS with 0.02% sodium azide and 50% glycerol pH 7.3.|
|Storage Conditions||Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage.|
SLC24A4, also named as NCKX4, belongs to the sodium/potassium/calcium exchanger family. SLC24A4 transports 1 Ca2+ and 1 K+ in exchange for 4 Na+. Genetic variations in SLC24A4 are associated with skin/hair/eye pigmentation type 6 (SHEP6).
Deletion of epithelial cell-specific p130Cas impairs the maturation stage of amelogenesis.
Cells Tissues Organs
Expression of the sodium/calcium/potassium exchanger, NCKX4, in ameloblasts.
Calcif Tissue Int
Reduced Protein Expression of the Na(+)/Ca(2+)+K(+)-Exchanger (SLC24A4) in Apical Plasma Membranes of Maturation Ameloblasts of Fluorotic Mice.
J Cell Physiol
Identification of novel candidate genes involved in mineralization of dental enamel by genome-wide transcript profiling.