Product Information
86163-1-PBS targets SLC25A22 in applications and shows reactivity with human samples.
Tested Reactivity | human |
Host / Isotype | Rabbit / IgG |
Class | Recombinant |
Type | Antibody |
Immunogen | SLC25A22 fusion protein Ag19958 Predict reactive species |
Full Name | solute carrier family 25 (mitochondrial carrier: glutamate), member 22 |
Calculated Molecular Weight | 323 aa, 34 kDa |
Observed Molecular Weight | 30-34 kDa |
GenBank Accession Number | BC023545 |
Gene Symbol | SLC25A22 |
Gene ID (NCBI) | 79751 |
Conjugate | Unconjugated |
Form | Liquid |
Purification Method | Protein A purification |
UNIPROT ID | Q9H936 |
Storage Buffer | PBS only, pH 7.3. |
Storage Conditions | Store at -80°C. |
Background Information
SLC25A22 encodes a mitochondrial glutamate/H+ symporter with highly expression in brain, especially in astrocytes, where it controls glutamate uptake. The mutations of SLC25A22 are associated with the early/infantile epileptic encephalopathies. It has been shown that SLC25A22 plays a key role in promoting proliferation and migration in cancer, such as human colorectal cancer (CRC) and Gallbladder cancer (GBC). And there is a result that the expression of SLC25A22 in GBC was significantly higher than that in adjacent tissues. 25402-1-AP antibody is specific to SLC25A22.(PMID: 30814911, 25033742, 24596948)