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- KD/KO Validated
Syntaxin 6 Polyclonal antibody
Syntaxin 6 Polyclonal Antibody for IF, IHC, IP, WB, ELISA
Host / Isotype
Rabbit / IgG
human, mouse, rat
WB, IP, IHC, IF, FC, ELISA
Cat no : 10841-1-AP
Validation Data Gallery
|Positive WB detected in||Neuro-2a cells, human brain tissue, mouse brain tissue, rat brain tissue, PC-12 cells|
|Positive IP detected in||mouse brain tissue|
|Positive IHC detected in||mouse brain tissue, human prostate cancer tissue|
Note: suggested antigen retrieval with TE buffer pH 9.0; (*) Alternatively, antigen retrieval may be performed with citrate buffer pH 6.0
|Positive IF detected in||PC-12 cells, murine BM-DC, murine Spleen-DC|
|Western Blot (WB)||WB : 1:2000-1:12000|
|Immunoprecipitation (IP)||IP : 0.5-4.0 ug for IP and 1:500-1:2000 for WB|
|Immunohistochemistry (IHC)||IHC : 1:50-1:500|
|Immunofluorescence (IF)||IF : 1:50-1:500|
|Sample-dependent, check data in validation data gallery|
|KD/KO||See 1 publications below|
|WB||See 4 publications below|
|IF||See 11 publications below|
|FC||See 1 publications below|
10841-1-AP targets Syntaxin 6 in WB, IP, IHC, IF, FC, ELISA applications and shows reactivity with human, mouse, rat samples.
|Tested Reactivity||human, mouse, rat|
|Cited Reactivity||human, mouse, rat|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Syntaxin 6 fusion protein Ag1284|
|Full Name||syntaxin 6|
|Calculated molecular weight||29 kDa|
|Observed molecular weight||32 kDa|
|GenBank accession number||BC009944|
|Gene ID (NCBI)||10228|
|Purification Method||Antigen affinity purification|
|Storage Buffer||PBS with 0.02% sodium azide and 50% glycerol pH 7.3.|
|Storage Conditions||Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. 20ul sizes contain 0.1% BSA.|
Syntaxin-6 (STX6) is a SNARE protein located in the trans-Golgi network (TGN) and endosomes. It associates with a variety of SNARE proteins and is involved in intracellular vesicle trafficking. STX6 is required for sorting proteins from endosomes toward either the TGN or lysosomes.
|Product Specific Protocols|
|WB protocol for Syntaxin 6 antibody 10841-1-AP||Download protocol|
|IHC protocol for Syntaxin 6 antibody 10841-1-AP||Download protocol|
|IF protocol for Syntaxin 6 antibody 10841-1-AP||Download protocol|
|IP protocol for Syntaxin 6 antibody 10841-1-AP||Download protocol|
|Click here to view our Standard Protocols|
IRAP identifies an endosomal compartment required for MHC class I cross-presentation.
IRAP(+) endosomes restrict TLR9 activation and signaling.
IRAP-dependent endosomal T cell receptor signalling is essential for T cell responses.
Innate Immune Signals Induce Anterograde Endosome Transport Promoting MHC Class I Cross-Presentation.
Conventional dendritic cells require IRAP-Rab14 endosomes for efficient cross-presentation.
Over-expression of microRNA-1 causes arrhythmia by disturbing intracellular trafficking system.