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  • KD/KO Validated

SURVIVIN Polyclonal antibody

SURVIVIN Polyclonal Antibody for FC, IF, IHC, IP, WB,ELISA

Host / Isotype

Rabbit / IgG


human, mouse, rat and More (1)





Cat no : 10508-1-AP


API4, Apoptosis inhibitor 4, Apoptosis inhibitor survivin, BIRC5, EPR 1, IAP4, SURVIVIN

Tested Applications

Positive WB detected inHeLa cells, NIH/3T3 cells, PC-3 cells, Jurkat cells, A549 cells
Positive IP detected inU2OS cells, Jurkat cells
Positive IHC detected inhuman colon cancer tissue, human breast cancer tissue, human stomach cancer tissue
Note: suggested antigen retrieval with TE buffer pH 9.0; (*) Alternatively, antigen retrieval may be performed with citrate buffer pH 6.0
Positive IF detected inMCF-7 cells
Positive FC detected inJurkat cells
Planning an IF experiment? We recommend our CoraLite®488, CoraLite®555 and CoraLite®650 conjugated versions of this antibody.

Recommended dilution

Western Blot (WB)WB : 1:500-1:2000
Immunoprecipitation (IP)IP : 0.5-4.0 ug for IP and 1:500-1:2000 for WB
Immunohistochemistry (IHC)IHC : 1:200-1:800
Immunofluorescence (IF)IF : 1:50-1:500
Sample-dependent, check data in validation data gallery

Product Information

10508-1-AP targets SURVIVIN in WB, IP, IHC, IF, FC, ELISA applications and shows reactivity with human, mouse, rat samples.

Tested Reactivity human, mouse, rat
Cited Reactivityhuman, mouse, rat, hamster
Host / Isotype Rabbit / IgG
Class Polyclonal
Type Antibody
Immunogen SURVIVIN fusion protein Ag0788
Full Name baculoviral IAP repeat-containing 5
Calculated molecular weight 16 kDa
Observed molecular weight 16-18 kDa
GenBank accession numberBC008718
Gene symbol BIRC5
Gene ID (NCBI) 332
Conjugate Unconjugated
Form Liquid
Purification Method Antigen affinity purification
Storage Buffer PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Storage ConditionsStore at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage.

Background Information

Survivin, also called BIRC5, is a unique member of the inhibitor of apoptosis (IAP) protein family. Survivin is a 16 kDa anti-apoptotic protein highly expressed during fetal development and cancer cell malignancy, but is completely absent in terminally differentiated cells. The differential expression of survivin in cancer versus normal tissues makes it a useful tool in cancer diagnosis and a promising therapeutic target. Survivin expression is also highly regulated by the cell cycle and is only expressed in the G2-M phase. It is known that survivin localizes to the mitotic spindle by interaction with tubulin during mitosis and may play a contributing role in regulating mitosis. Disruption of survivin-microtubule interactions results in loss of survivin's anti-apoptosis function and increased caspase-3 activity, a mechanism involved in cell death, during mitosis. It also is a direct target gene of the Wnt pathway and is upregulated by beta-catenin.


Product Specific Protocols
WB protocol for SURVIVIN antibody 10508-1-APDownload protocol
IHC protocol for SURVIVIN antibody 10508-1-APDownload protocol
IF protocol for SURVIVIN antibody 10508-1-APDownload protocol
IP protocol for SURVIVIN antibody 10508-1-APDownload protocol
FC protocol for SURVIVIN antibody 10508-1-APDownload protocol
Standard Protocols
Click here to view our Standard Protocols



Clin Sci (Lond)

PMID: 30782607

Authors - Chao Liu


Myricetin Suppresses the Propagation of Hepatocellular Carcinoma via Down-Regulating Expression of YAP.

Authors - Minjing Li

Life Sci

Synergistic effects of 7-O-geranylquercetin and siRNAs on the treatment of human breast cancer.

Authors - Jiaxin Zuo


A Noncoding Regulatory RNAs Network Driven by Circ-CDYL Acts Specifically in the Early Stages Hepatocellular Carcinoma.

Authors - Yanping Wei

Biomed Pharmacother

PMID: 30021341

Authors - Chao Wang

J Oral Pathol Med

PMID: 30053324

Authors - Xia Wang


The reviews below have been submitted by verified Proteintech customers who received an incentive forproviding their feedback.


Susmita (Verified Customer) (08-21-2020)

Giving good result and crisp band in Western Blot.

  • Applications: Western Blot
  • Primary Antibody Dilution: 1:1000
  • Cell Tissue Type: Pancreatic cell line
SURVIVIN Antibody Western Blot validation (1:1000 dilution) in Pancreatic cell line (Cat no:10508-1-AP)

Iram (Verified Customer) (08-14-2020)

We got very sharp and clean band of survivin with this antibody.

  • Applications: Western Blot
  • Primary Antibody Dilution: 1:2000
  • Cell Tissue Type: Human colon cancer