SUZ12 Polyclonal antibody, PBS Only

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• SUZ12 Polyclonal antibody, PBS Only (20366-1-PBS)

• 

  WB analysis using 20366-1-AP (same clone as 20366-1-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 20366-1-AP (SUZ12 antibody) at dilution of 1:3000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 20366-1-PBS in a different storage buffer formulation.

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  WB analysis of HEK-293 using 20366-1-AP (same clone as 20366-1-PBS)

  WB result of SUZ12 antibody (20366-1-AP; 1:1200; incubated at room temperature for 1.5 hours) with sh-Control and sh-SUZ12 transfected HEK-293 cells. This data was developed using the same antibody clone with 20366-1-PBS in a different storage buffer formulation.

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  IP experiment of HeLa using 20366-1-AP (same clone as 20366-1-PBS)

  IP result of anti-SUZ12 (IP:20366-1-AP, 4ug; Detection:20366-1-AP 1:500) with HeLa cells lysate 3200ug. This data was developed using the same antibody clone with 20366-1-PBS in a different storage buffer formulation.

• 

  IP experiment of HeLa using 20366-1-AP (same clone as 20366-1-PBS)

  IP result of anti-SUZ12 (IP:20366-1-AP, 4ug; Detection:20366-1-AP 1:500) with HeLa cells lysate 3200ug. This data was developed using the same antibody clone with 20366-1-PBS in a different storage buffer formulation.

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  IHC staining of human breast cancer using 20366-1-AP (same clone as 20366-1-PBS)

  Immunohistochemical analysis of paraffin-embedded human breast cancer slide using 20366-1-AP (SUZ12 Antibody) at dilution of 1:400. This data was developed using the same antibody clone with 20366-1-PBS in a different storage buffer formulation.

• 

  IHC staining of human breast cancer using 20366-1-AP (same clone as 20366-1-PBS)

  Immunohistochemical analysis of paraffin-embedded human breast cancer slide using 20366-1-AP (SUZ12 Antibody) at dilution of 1:100. This data was developed using the same antibody clone with 20366-1-PBS in a different storage buffer formulation.

• 

  IHC staining of human breast cancer using 20366-1-AP (same clone as 20366-1-PBS)

  Immunohistochemical analysis of paraffin-embedded human breast cancer slide using 20366-1-AP (SUZ12 Antibody) at dilution of 1:100. This data was developed using the same antibody clone with 20366-1-PBS in a different storage buffer formulation.

• 

  IHC staining of human breast cancer using 20366-1-AP (same clone as 20366-1-PBS)

  Immunohistochemical analysis of paraffin-embedded human breast cancer slide using 20366-1-AP (SUZ12 Antibody) at dilution of 1:200. This data was developed using the same antibody clone with 20366-1-PBS in a different storage buffer formulation.

• 

  IHC staining of human breast cancer using 20366-1-AP (same clone as 20366-1-PBS)

  Immunohistochemical analysis of paraffin-embedded human breast cancer slide using 20366-1-AP (SUZ12 Antibody) at dilution of 1:200. This data was developed using the same antibody clone with 20366-1-PBS in a different storage buffer formulation.

• 

  IHC staining of human breast cancer using 20366-1-AP (same clone as 20366-1-PBS)

  Immunohistochemical analysis of paraffin-embedded human breast cancer slide using 20366-1-AP (SUZ12 Antibody) at dilution of 1:400. This data was developed using the same antibody clone with 20366-1-PBS in a different storage buffer formulation.

• Featured Product
• KD/KO Validated

SUZ12 Polyclonal Antibody for WB, IHC, IP, Indirect ELISA

Cat No. 20366-1-PBS

Host / Isotype

Rabbit / IgG

Reactivity

human, rat

Applications

WB, IHC, IP, Indirect ELISA

Synonyms

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Product Information

20366-1-PBS targets SUZ12 in WB, IHC, IP, Indirect ELISA applications and shows reactivity with human, rat samples.

• Tested Reactivity: human, rat
• Host / Isotype: Rabbit / IgG
• Class: Polyclonal
• Type: Antibody
• Immunogen:

  Peptide

• Full Name: suppressor of zeste 12 homolog (Drosophila)
• Calculated Molecular Weight: 83 kDa
• Observed Molecular Weight: 80-90 kDa
• GenBank Accession Number: NM_015355
• Gene Symbol: SUZ12
• Gene ID (NCBI): 23512
• RRID: AB_10694152
• Conjugate: Unconjugated
• Form: Liquid
• Purification Method: Antigen affinity purification
• UNIPROT ID: Q15022
• Storage Buffer: PBS only, pH 7.3.
• Storage Conditions: Store at -80°C.

Background Information

SUZ12, also termed CHET9, JJAZ1 or KIAA0160, belongs to the VEFS (VRN2-EMF2-FIS2-SU(Z)12) family. It is a polycomb group (PcG) protein. SUZ12 is a component of the PRC2/EED-EZH2 complex, which methylates 'Lys-9' and 'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene. The PRC2/EED-EZH2 complex may also serve as a recruiting platform for DNA methyltransferases, thereby linking two epigenetic repression systems. Genes repressed by the PRC2/EED-EZH2 complex include HOXC8, HOXA9, MYT1 and CDKN2A. A chromosomal aberration involving SUZ12 may be a cause of endometrial stromal tumors.