SV2C Recombinant monoclonal antibody, PBS Only

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• SV2C Recombinant monoclonal antibody, PBS Only (88136-1-PBS)

SV2C Uni-rAb^® Recombinant Antibody for WB, Indirect ELISA

Cat No. 88136-1-PBS

Clone No.260377A4

Host / Isotype

Rabbit / IgG

Reactivity

human, mouse, rat

Applications

WB, Indirect ELISA

Synonyms

Synaptic vesicle glycoprotein 2C

• 

  WB analysis using 88136-1-RR (same clone as 88136-1-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 88136-1-RR (SV2C antibody) at dilution of 1:10000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 88136-1-PBS in a different storage buffer formulation.

  This validation data has been generated in-house and reviewed by Proteintech scientists. Find out more on our antibody validation policy
• 

  WB analysis using 88136-1-RR (same clone as 88136-1-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 88136-1-RR (SV2C antibody) at dilution of 1:10000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 88136-1-PBS in a different storage buffer formulation.

  This validation data has been generated in-house and reviewed by Proteintech scientists. Find out more on our antibody validation policy

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Product Information

88136-1-PBS targets SV2C in WB, Indirect ELISA applications and shows reactivity with human, mouse, rat samples.

• Tested Reactivity: human, mouse, rat
• Host / Isotype: Rabbit / IgG
• Class: Recombinant
• Type: Antibody
• Immunogen:

  CatNo: Eg9076

  Product name: Recombinant human SV2C protein

  Source: mammalian cells-derived, V37

  Tag: C-rFc

  Domain: 459-578 aa of NM_014979.4

  Sequence: KPLQSDEYALLTRNVERDKYANFTINFTMENQIHTGMEYDNGRFIGVKFKSVTFKDSVFKSCTFEDVTSVNTYFKNCTFIDTVFDNTDFEPYKFIDSEFKNCSFFHNKTGCQITFDDDYS

• Full Name: synaptic vesicle glycoprotein 2C
• Calculated Molecular Weight: 83 kDa
• Observed Molecular Weight: 120 kDa
• GenBank Accession Number: NM_014979.4
• Gene Symbol: SV2C
• Gene ID (NCBI): 22987
• Conjugate: Unconjugated
• Form: Liquid
• Purification Method: Protein A purification
• UNIPROT ID: Q496J9
• Storage Buffer: PBS only, pH 7.3.
• Storage Conditions: Store at -80°C.

Background Information

Members of the synaptic vesicle glycoprotein 2 (SV2) family of proteins are involved in synaptic function throughout the brain. The ubiquitously expressed SV2A has been widely implicated in epilepsy, SV2C as a mediator of dopamine homeostasis and report that disrupted expression of SV2C within the basal ganglia is a pathological feature of PD. Genetic deletion of SV2C leads to reduced dopamine release in the dorsal striatum as measured by fast-scan cyclic voltammetry, reduced striatal dopamine content, disrupted α-synuclein expression, deficits in motor function, and alterations in neurochemical effects of nicotine. SV2C has a calculated molecular weight of ~82 kDa, but is detected at ~120 kDa by Western blot. This discrepancy is mainly due to extensive N‑glycosylation.